Results 71 to 80 of about 307,069 (265)

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

DYNAMICS CHARACTERISTICS AND EXPERIMENTAL ANALYSIS ON THE OBLIQUE CUTTING OF PLOW SYSTEM

open access: yesJixie qiangdu, 2019
Aiming at the mechanical properties of plow head and dynamic charateristics of system under oblique cutting condition,cutting resistance of planning tool under oblique cutting condition was derived,and was treated as external excitation.
ZHANG Yu   +3 more
doaj  

Mining method for cutting force coefficient with the impact of tool vibration and machine tool system

open access: yesAdvances in Mechanical Engineering
The cutting characteristics observed in machining processes are significantly influenced by a combination of various dynamic parameters as well as the overall machine tool system in use.
Xi Chen   +5 more
doaj   +1 more source

Dynamic characteristics analysis of automatic cutting and profiling control system for roadheader

open access: yesGong-kuang zidonghua, 2015
An analysis method was proposed for dynamic characteristics of automatic cutting and profiling control system for roadheader base on transfer function model. Composition and main structure of the system were expounded, and transfer function model of each
TIAN Jie, WANG Hongyao, WU Miao
doaj   +1 more source

The accuracy of an extramedullary femoral cutting system in total knee arthroplasty in patients with severe coronal femoral bowing: a radiographic study. [PDF]

open access: yesJ Orthop Surg Res, 2022
Wang Q   +12 more
europepmc   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

open access: yesMolecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel   +6 more
wiley   +1 more source

Plastic Sample Cutting System

open access: yes, 2018
The goal of this project was to provide Winpak with a solution to cut two different sizes of samples; 8 in x 10 in and 10 cm x 10 cm rectangles for samples of up to 600 microns in thickness. The solution provided would primarily need to be safe, require less force to eliminate physical strain for the operator, be easy to use and reduce the overall ...
Poo-Cheong, Dean Tin Vee How   +3 more
openaire   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

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