Results 71 to 80 of about 319,295 (264)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Abrasive Waterjet (AWJ) Forces-Indicator of Cutting System Malfunction. [PDF]

Materials (Basel), 2021
Hlaváč LM, Bańkowski D, Krajcarz D, Štefek A, Tyč M, Młynarczyk P.   +5 more
europepmc   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Turning Tool Wear Estimation Based on the Calculated Parameter Values of the Thermodynamic Subsystem of the Cutting System. [PDF]

Materials (Basel), 2021
Lapshin VP.
europepmc   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Experimental Investigation of the Effects of Coolant Temperature on Cutting Tool Wear in the Machining Process

Machines
In machining processes, the heat generated in the cutting zone varies depending on cutting parameters such as depth of cut, cutting speed and feed rate.
Osman Şahin, Durmuş Karayel, Mustafa Ali Ertürk, Ergün Nart, Ömer Seçgin   +4 more
doaj   +1 more source

The accuracy of an extramedullary femoral cutting system in total knee arthroplasty in patients with severe coronal femoral bowing: a radiographic study. [PDF]

J Orthop Surg Res, 2022
Wang Q, Zhang X, Shi T, Bao Z, Wang B, Yao Y, Wu D, Liu Z, Cai H, Chen D, Dai J, Jiang Q, Xu Z.   +12 more
europepmc   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

DYNAMICS CHARACTERISTICS AND EXPERIMENTAL ANALYSIS ON THE OBLIQUE CUTTING OF PLOW SYSTEM

Jixie qiangdu, 2019
Aiming at the mechanical properties of plow head and dynamic charateristics of system under oblique cutting condition,cutting resistance of planning tool under oblique cutting condition was derived,and was treated as external excitation.
ZHANG Yu, CHEN HongYue, HAO ZhiYong, MAO Jun   +3 more
doaj  

Piezoelectric Hysteresis Modeling of Hybrid Driven Three-Dimensional Elliptical Vibration Aided Cutting System Based on an Improved Flower Pollination Algorithm. [PDF]

Micromachines (Basel), 2021
Fu X, Gong H, Lu M, Zhou J, Lin J, Du Y, Zhou R.   +6 more
europepmc   +1 more source