Results 121 to 130 of about 260,054 (360)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Effects of Potassium, Sulfur, Nitrogen Rate, And Nitrogen Source on Bromegrass Forage Yield and Composition [PDF]
, 1987 Production of adequate , high-quality forage is essential for Alaska's livestock industry. Smooth bromegrass (Bromus inermis) is the dominant and most dependable perennial forage crop in the Matanuska Valley and other areas of Alaska.
Laughlin, Winston M. +2 more
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Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Effect of hormones, light and media treatments on rooting of Juniperus oblonga cuttings [PDF]
مجله جنگل ایران, 2012 Due to several problems in natural regeneration of Juniperus oblonga, asexual reproduction has important implication in restoring the habitat of this species. The aim of this study was to investigate the effects of different treatments including hormones,
doaj
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
TREX1, a predator for treating MSI‐H tumors?
Molecular Oncology, EarlyView.Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya +2 more
wiley +1 more source
Timothy in Alaska: Characteristics, History, Adaptation, and Management [PDF]
, 1997 This report (a) summarizes the characteristics of timothy (Phleum pratense L.) as a forage species, (b) reviews briefly the history of its use in the U.S., and the history of timothy evaluations and culture in Alaska, (c) compares winterhardiness of ...
Klebesadel, Leslie J.
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ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Early ontogenetic male cone production in Pinus radiata : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Plant Biology at Massey University [PDF]
, 2000 The tree breeding industry is interested in early ontogenetic male cone production in Pinus radiata in order to maximise the rate at which successive generations can be bred.
Welsh, Shayne Kevin
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