Results 71 to 80 of about 36,594 (313)
Dealing with uncertainty in cyberspace
Computers & Security, 2023 While cyberspace as a globally interconnected network offers economic, social and informational potential, at the same time this space also produces a wide variety of risks, for which no easy solutions exist. For the international community, for nation states, for organizations and even for individuals, uncertainty is a common thread for interaction ...
openaire +2 more sources
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Muddy rules for cyberspace: Musings of a she-blogger [PDF]
‘Muddy rules for cyberspace’: Musings of a she-blogger. Yvonne Downs Although referring specifically to intellectual property rights, the above quotation from Burk (1998) gives a sense of the complex, emergent, often ambiguous terms on which we enter ...
Downs, Yvonne
core
Gentle-Sketch: a high-performance and compact invertible sketch for top-K estimation
Scientific ReportsTop-k estimation has been a significant research focus in network data stream processing, owing to its broad range of applications. However, the rapid detection of top-k frequent flows in massive network traffic poses considerable challenges, primarily ...
Yao Xin +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Security analysis of blockchain-based cryptocurrency [PDF]
BlockchainCryptocurrency is a novel exploration of a form of currency that proposes a decentralized electronic payment scheme based on blockchain technology and cryptographic theory.
Zekai Liu +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Introduction: Security in Cyberspace [PDF]
, 2014 This chapter is the introduction to the volume of the same title.
GIACOMELLO, GIAMPIERO
core
Complex & Intelligent SystemsDue to the increasing sophistication of face forgery techniques, the images generated are becoming more and more realistic and difficult for human eyes to distinguish.
Hanxian Duan +7 more
doaj +1 more source