Results 81 to 90 of about 923,106 (207)

Neuroprotective effect of normal and modified mesenchymal stem cell‐derived exosomes by mitigating Alzheimer's‐related oxidative and inflammatory damage via Nrf2/HO‐1 in SH‐SY5Y cells

open access: yesIbrain, EarlyView.
Exosome therapy shows promise in Alzheimer's disease. This study compared normal and modified exosomes from AD brain extract‐treated MSCs in STZ‐induced SH‐SY5Y cells. Exosomes improved neuronal viability, reduced oxidative stress and inflammation, and activated Nrf2/HO‐1 signaling.
Rishika Dhapola   +4 more
wiley   +1 more source

Human biomarker navigator

open access: yesiMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li   +29 more
wiley   +1 more source

Must Longtermists Wish Us All Dead? A Quadrilemma

open access: yesJournal of Applied Philosophy, EarlyView.
ABSTRACT Longtermists assign great moral importance to making the long‐term future as good as possible, especially by ensuring the survival of humanity. We argue, to the contrary, that on assumptions that are plausible, conservative, or shared by leading longtermists, human extinction will likely augment total utility among human and non‐human animals ...
Nir Eyal, Bastian Steuwer, Shai Meiri
wiley   +1 more source

A Kullback-Liebler divergence-based representation algorithm for malware detection. [PDF]

open access: yesPeerJ Comput Sci, 2023
Aboaoja FA   +5 more
europepmc   +1 more source

Report of Secretary of Defense to the Congress on the ... Defense budget and ... Defense program.

open access: yes
Includes transition budgets, authorization request and defense programs.Title varies slightly.Report year ends June 30.Mode of access ...
United States. Dept. of Defense.
core  

Cyberspace security: How to develop a security strategy

open access: yes, 2007
International audienceDespite all visible dividers, the Internet is getting us closer and closer, but with a great price. Our security is the price. The international community is fully aware of the urgent need to secure the cyberspace as you see the ...
Raggad, Bel, G., Sidhom, Sahbi
core  

Experiencing 50 Years of Synergistic Development in Structural Biology and Enzymology

open access: yesJournal of the Chinese Chemical Society, EarlyView.
Picture of Sunney Chan with Academia Sinica (AS) President James C. Liao and three Vice Presidents: Shin‐Kun Peng (left one), Tang K. Tang (right one), and Mei‐Yin Chou (right 2), taken at the annual Chinese New Year's Banquet of AS, February 7, 2025. This was likely Sunney's last appearance in formal activities of AS.
Ming‐Daw Tsai
wiley   +1 more source

Preliminary Development and Assessment of a Multiplex Assay for Human Papillomavirus Antibody Detection Using Commercial L1 Proteins

open access: yesJournal of Clinical Laboratory Analysis, EarlyView.
This study developed and assessed a new multiplex assay for the simultaneous detection of antibodies against multiple Human Papillomavirus (HPV) types. Using recombinant L1 protein, the assay quantifies IgG and IgA responses in human plasma, enabling comprehensive immune profiling across multiple high‐risk cancer‐associated HPV genotypes. This approach
Arash Aslanabadi   +11 more
wiley   +1 more source

Mycotoxin management in the cereal supply chain: Advanced detection, detoxification, and smart packaging strategies

open access: yesJournal of the Science of Food and Agriculture, EarlyView.
Abstract Mycotoxins remain a persistent threat to the safety and quality of cereal grains and other agricultural products, and their impact on human health continues to raise global concerns. In many situations, the practices traditionally used to control these toxins are no longer sufficiently effective. They can be costly, difficult to implement on a
Abolfazl Asqardokht‐Aliabadi   +2 more
wiley   +1 more source

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