Results 301 to 310 of about 87,184 (381)

Antimicrobial Peptides: Mechanisms, Applications, and Therapeutic Potential. [PDF]

Infect Drug Resist
Alzain M, Daghistani H, Shamrani T, Almoghrabi Y, Daghistani Y, Alharbi OS, Sait AM, Mufrrih M, Alhazmi W, Alqarni MA, Saleh BH, Zubair MA, Juma NA, Niyazi HA, Niyazi HA, Halabi WS, Altalhi R, Kazmi I, Altayb HN, Ibrahem K, Alfadil A.   +20 more
europepmc   +1 more source

Combating muscle atrophy: emerging therapeutic targets that are fiber‐type‐specific

The FEBS Journal, EarlyView.
Inflammation, denervation or decreased insulin signaling activate proteolysis and cause muscle wasting. Pathological conditions like obesity and DMD can also exacerbate atrophy via PGD2–RhoA–ROCK2 signaling. In contrast, exercise, dietary interventions, and pharmacological agents can activate Ca2+/calcineurin–NFAT and AMPK–PGC‐1α–MEF pathways ...
Samrat Chakraborty, Raz Ben‐David, Shenhav Shemer   +2 more
wiley   +1 more source

Sterile inflammation in MASH: emerging role of extracellular RNA and therapeutic strategies. [PDF]

NPJ Metab Health Dis
Raza S, Mahamood R, Medhe P, Shahi A, Yadav A, Tewari A, Sinha RA.   +6 more
europepmc   +1 more source

Propionibacterium acnes evades microbicidal phagocytosis by inhibiting the mitochondrial biogenesis of nucleus pulposus cells

The FEBS Journal, EarlyView.
P. acnes infection impairs the mitochondrial biogenesis of nucleus pulposus cells (NPCs) through the AMPK/SIRT‐1/PGC‐1α signaling pathway. This results in impaired mitochondria that are unable to generate sufficient ATP, and impaired delivery of mitochondrial reactive oxygen species to carry out the bactericidal process effectively.
Lemeng Ren, Changwei Li, Juntao Sun, Yuehuan Zheng, Yucheng Jiao, Jiancheng Zheng, Fangke Zhang, Yazhou Lin, Wenjian Wu, Peng Cao   +9 more
wiley   +1 more source

Activation of cellular responses by cyclic dinucleotides and porphyromonas gingivalis lipopolysaccharide: a proteomic study on gingival fibroblasts. [PDF]

J Oral Microbiol
Elmanfi S, Onyedibe KI, Aryal UK, Könönen E, Sintim HO, Gürsoy UK.   +5 more
europepmc   +1 more source

Multi‐pathway‐driven hepatic protection: Semaglutide combined with HIIT counteracts diabetic liver injury in db/db mice

Journal of Diabetes Investigation, EarlyView.
This study reveals that the new drug semaglutide combined with high‐intensity interval training is significantly better than a single drug in improving liver metabolic abnormalities in type 2 diabetes. Untargeted metabolomics studies showed that the synergistic effect was mainly achieved by regulating key pathways such as the TCA cycle, amino acid ...
Wenjun Yu, Yongfu Liu, Shenglong Le, Yuxin Xiao, Xiaoyan Chen, Junhua Wang, Feng Gao   +6 more
wiley   +1 more source

The machinery of healthy vasodilatation: an overview. [PDF]

Pflugers Arch
Pourová J, Dias P, Pour M, Mladěnka P.
europepmc   +1 more source

Zhinao Capsule Improved Sleep and Memory Disorders in APP/PS1 Mice via cAMP/PKA/CREB Signaling Pathway Modulation. [PDF]

Drug Des Devel Ther
Xi H, Xie W, Yang Y, Li X, Zhai S, Fang S, Yang Y, Rao Z, Yang W, Li H.   +9 more
europepmc   +1 more source

Cellular senescence in kidney diseases. [PDF]

Chin Med J (Engl)
Wang X, Li Y, Chu Q, Lv H, Li J, Yi F.
europepmc   +1 more source

A novel innate immunity-mediated senescence mechanism regulated by cGAS-STING-IRF3-pRB. [PDF]

MedComm (2020)
Zhou L, Li J, Chu WK.
europepmc   +1 more source