Results 81 to 90 of about 305,381 (270)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

Two-dimensional cyclic codes over a finite chain ring

open access: yesAnalele Stiintifice ale Universitatii Ovidius Constanta: Seria Matematica
In this paper, we have determined the generators and rank of a 2D cyclic code of length mn over a finite chain ring ℛ with residue field 𝔽q, where m is arbitrary and q ≡ 1(mod n).
Garg Disha, Dutt Sucheta
doaj   +1 more source

Polar Codes With Repeating Bits and the Construction by Cluster Pairwise Error Probability

open access: yesIEEE Access, 2019
A polar code with repeating bits (RB polar code), where a part of frozen bits only repeat their preceding information bits, is proposed. In the code construction, we propose cluster pairwise error probability (CPEP) to measure the competitiveness of the ...
Tao Wang, Daiming Qu, Tao Jiang
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

On Double Cyclic Codes and Applications to DNA Codes

open access: yesMathematics
In this paper, we investigate the structure of double cyclic codes of length (α,β) over R=F4+ϱF4,ϱ2=0 and give a minimal spanning set of double cyclic codes. Moreover, we extend this study to construct DNA codes from R-double cyclic codes.
Amal S. Alali   +2 more
doaj   +1 more source

A relation between quasi-cyclic codes and 2-D cyclic codes

open access: yesFinite Fields and Their Applications, 2012
We consider a q-ary quasi-cyclic code C of length m' and index ', where both m and ' are relatively prime to q. If the constituents of C are cyclic codes, we show that C can also be viewed as a 2-D cyclic code of size m *l ' over Fq. If we further assume that m and ' are also coprime to each other, then we easily observe that the code C must be ...
Cem Güneri, Ferruh Özbudak
openaire   +7 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

New bound of algebraic immunity of a class of Boolean function

open access: yesTongxin xuebao, 2016
Algebraic immunity quantified the resistance of a Boolean function to the algebraic attack.Recently,Mesnager,et al showed that there were direct linked between the annihilators used in algebraic attacks and the coding theory.They showed that the lower ...
Ye TIAN   +3 more
doaj  

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