Results 141 to 150 of about 3,681 (193)

Exploring the seas for cancer cures: the promise of marine-derived bioactive peptide. [PDF]

Int J Biochem Mol Biol
Rafieezadeh D, Abbaspour M.
europepmc   +1 more source

Straightforward, scalable, solution-phase synthesis of peptide bonds in flow. [PDF]

J Flow Chem
Wilson ZE, Lopez E, Flodén NJ, Watkins C, Bianchini G, Ley SV.   +5 more
europepmc   +1 more source

Marine Natural Products in Preclinical Cancer Studies: Ten Years of Advanced Total Synthesis. [PDF]

Mar Drugs
Colarusso E, Giordano A, Chini MG, Bifulco G, Lauro G.   +4 more
europepmc   +1 more source

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Macrocyclization strategies for the total synthesis of cyclic depsipeptides

Organic & Biomolecular Chemistry, 2023
Cyclic depsipeptides, bioactive natural products containing ester(s) and amides in the macrocycle, are synthesizedvia3 strategies, macrolactamization in solution, macrolactamization on-resin, and macrolactonization.
André R. Paquette, Christopher N. Boddy
openaire   +2 more sources

The Cyclic Depsipeptide Backbone of the Didemnins

Acta Crystallographica Section C Crystal Structure Communications, 1995
An X-ray crystal analysis of phi-lactone N-¿1-¿N-¿4-¿[3- hydroxy-5-methyl-1-oxo-4-(N-L-threonylamino)heptyl]- oxy¿-2,5-dimethyl-1,3-dioxohexyl¿-L-leucyl¿-L-prolyl¿- N,O-dimethyl-L-tyrosine hydrobromide hydrate (1a), C42H66N5O11+.Br-.H2O, was obtained in order to determine the backbone folding of the macrocycle and to compare the results obtained with ...
S C, Mayer, P J, Carroll, M M, Joullié
openaire   +2 more sources

Cyclic Depsipeptides, Callipeltins

2020
Marine sponges are considered as an untapped reservoir of biologically active natural compounds exhibiting numerous interesting and potentially useful pharmacological activities, including antimicrobial, antifungal, cytotoxic, anti-inflammatory, and immunostimulatory activities.
Reda A. Abdelhamid, Hiroyuki Konno
openaire   +1 more source

Cyclic depsipeptides as potential cancer therapeutics

Anti-Cancer Drugs, 2015
Cyclic depsipeptides are polypeptides in which one or more amino acid is replaced by a hydroxy acid, resulting in the formation of at least one ester bond in the core ring structure. Many natural cyclic depsipeptides possessing intriguing structural and biological properties, including antitumor, antifungal, antiviral, antibacterial, anthelmintic, and ...
Jirouta, Kitagaki, Genbin, Shi, Shizuka, Miyauchi, Shinya, Murakami, Yili, Yang   +4 more
openaire   +2 more sources

Total Synthesis of the Marine Cyclic Depsipeptide Viequeamide A

Journal of Natural Products, 2013
The first total synthesis of viequeamide A, a natural cyclic depsipeptide isolated from a marine button cyanobacterium, was achieved with the N-Me-Val-Thr peptide bond as the final macrocyclization site. The synthetic product gave nearly identical spectroscopic data to that reported for the natural product.
Dongyu, Wang, Shanshan, Song, Ye, Tian, Youjun, Xu, Zehong, Miao, Ao, Zhang   +5 more
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Total synthesis of aureobasidin a, an antifungal cyclic depsipeptide

Chemistry Letters, 1993
Abstract A total synthesis of an antifungal cyclic depsipeptide aureobasidin A was first achieved mainly using PyBroP1) as a coupling reagent. The synthetic cyclized product was completely identical with the natural antibiotic in all respects. Some unexpected reactions due to N-methylamino acid were also described.
Toru Kurome, Kaoru Inami, Tetsuya Inoue, Katsushige Ikai, Kazutoh Takesako, Ikunoshin Kato, Tetsuo Shiba   +6 more
openaire   +1 more source