Results 271 to 280 of about 84,969 (338)

Adenosine relaxes vagina smooth muscle through the cyclic guanosine monophosphate– and cyclic guanosine monophosphate–dependent pathways

The Journal of Sexual Medicine
Abstract Background In males, adenosine (ADO) is known to relax penile smooth muscles, although its role in the vagina is not yet fully elucidated. Aim This study investigated the effect of ADO on vagina smooth muscle activity, using ...
Cellai, Ilaria, Filippi, Sandra, Comeglio, Paolo, Guarnieri, Giulia, Acciai, Gabriele, Cancedda, Chiara, Cipriani, Sarah, Maseroli, Elisa, Rastrelli, Giulia, Morelli, Annamaria, Maggi, Mario, Vignozzi, Linda   +11 more
openaire   +3 more sources

Cyclic Guanosine Monophosphate and Cellular Growth [PDF]

Science, 1975
The addition of serum to nongrowing cells decreases cyclic guanosine monophosphate and cyclic adenosine monophosphate levels and promotes cell growth.
Z Miller, Ira Pastan, Maria Gallo, Elizabeth Lovelace   +3 more
openaire   +3 more sources

Smart Liposomal Nanocarrier Enhanced the Treatment of Ischemic Stroke through Neutrophil Extracellular Traps and Cyclic Guanosine Monophosphate-Adenosine Monophosphate Synthase-Stimulator of Interferon Genes (cGAS-STING) Pathway Inhibition of Ischemic Penumbra.

ACS Nano, 2023
Brain inflammation is regarded as one of the leading causes that aggravates secondary brain injury and hinders the prognosis of ischemic stroke. After ischemic stroke, high quantities of peripheral neutrophils are recruited to brain lesions and release ...
Shanbo Sun, Wei Lv, Shengnan Li, Qi Zhang, Weichong He, Zhiyi Min, C. Teng, Yuqin Chen, Linfeng Liu, Jiaqing Yin, Baoli Zhu, Ming Xu, Dongwei Dai, Hongliang Xin   +13 more
semanticscholar   +1 more source

Cyclic guanosine monophosphate (GMP) levels in ocular tissues [PDF]

Albrecht von Graefes Archiv f�r Klinische und Experimentelle Ophthalmologie, 1977
The cyclic 3′5′ guanosine monophosphate (cGMP) content of tissues of the rabbit eye was studied. Very high levels of the cyclic nucleotide were detected in the retina and rather high ones in the choroid and vitreous body, while the levels found in the iris, lens, and aqueous humor were many times lower.
Laura Tomazzoli, Iva Fregona, Luciano Bonomi   +2 more
openaire   +2 more sources

Effect of Angiotensin II on Cyclic Guanosine Monophosphate and Cyclic Adenosine Monophosphate in Human Plasma

The Journal of Clinical Endocrinology & Metabolism, 1976
Infusion of alpha-adrenergic catecholamines increases plasma cyclic guanosine monophosphate (pcGMP), raising the possibility that the pressor effect of these agents may be mediated by cyclic GMP. We infused pressor doses of angiotensin II in 10 studies in 8 normal subject and measured pcGMP and plasma cyclic adenosine monophosphate (pcAMP) by ...
David Goodman, Paul M. Rosman, Alton L. Steiner, Ram Agrawal   +3 more
openaire   +3 more sources

Hydrolysis of cyclic guanosine monophosphate and cyclic adenosine monophosphate by the penis and aorta of the diabetic rat

British Journal of Urology, 1996
Objective To investigate the hydrolysis of adenosine 3′5′‐cyclic monophosphate (cAMP) and guanosine 3′5′‐cyclic monophosphate (cGMP) by specific phosphodiesterases (PDEs) in the penis and aorta of diabetic rats.Materials and methods Non‐ketonuric diabetes mellitus was induced in 10 Sprague‐Dawley rats with streptozotocin.
M. A. W. Miller, Dimitri P. Mikhailidis, J.Y. Jeremy, Cecil S. Thompson, Robert J. Morgan   +4 more
openaire   +3 more sources

Action of Cyclic Guanosine Monophosphate on Thyroid Weight and Protein

Endocrinology, 1971
In previous studies, cyclic adenosine monophosphate was found to stimulate mouse thyroid protein synthesis and growth. These investigations were extended in the present study, in which the action of 3',5'-cylic guanosine monophosphate (c-GMP) was investigated. One or 2 mg/day of c-GMP given for 5 days to thyroxine-suppressed mice stimulated L-H-leucine
Mario A. Pisarev, John F. Wilber, Noe Altschuler, Leslie J. DeGroot   +3 more
openaire   +3 more sources

Cellular signaling with nitric oxide and cyclic guanosine monophosphate

Seminars in Perinatology, 2000
The understanding of the formation and biological actions of nitric oxide (NO) has grown extensively during the past two decades. With the discoveries of the biological effects of NO and nitrovasodilators on cyclic guanosine monophosphate, with the elucidation of the biochemical mechanisms of NO synthesis, and with the growing knowledge of regulation ...
Yu Chen Lee, Ferid Murad, Karen L. Davis, Ka Bian, Emil Martin   +4 more
openaire   +3 more sources

Atrial Natriuretic Peptides and Cyclic Guanosine Monophosphate Metabolism

The American Journal of the Medical Sciences, 1995
Atrial natriuretic factor (ANF), consisting of amino acids 99-126 of the 126 amino acid ANF prohormone, increases cyclic guanosine monophosphate (GMP) (thought to be the mediator of its physiologic effects) in plasma and urine of human subjects. Long-acting natriuretic peptide, vessel dilator, and kaliuretic peptide, consisting of amino acid 1-30, 31 ...
Margaret A. Douglass, George Rodriguez-Paz, Amy T. Giordano, Michael T. McCormick, Douglas D. Schocken, David L. Vesely   +5 more
openaire   +3 more sources

Cyclic Guanosine Monophosphate Mediates Penile Erection in the Rat

European Urology, 1993
Recent in vivo and in vitro studies suggest that nitric oxide or a nitric-oxide-like substance mediates nonadrenergic, noncholinergic relaxation of trabecular smooth muscle through activation of the cyclic guanosine monophosphate (cGMP) pathway. In 60 Sprague-Dawley rats, we investigated the effect of intracavernous administration of different drugs ...
Flavio Trigo-Rocha, Emil A. Tanagho, Geng-Long Hsu, Luis Martínez-Piñeiro, Tom F. Lue, B von Heyden   +5 more
openaire   +2 more sources