Results 291 to 300 of about 84,969 (338)

Injection of melatonin into cisterna magna increases concentration of 3', 5' cyclic guanosine monophosphate in cerebrospinal fluid.

Neuroendocrinology, 1976
Rabbits were anesthetized with urethane and were given intracisternal injections of the following substances: adrenocorticotropin, beta-melanocyte stimulating hormone, choroid plexus peptide IIF, epinephrine, serotonin, histamine, oxytocin, lysine and a ...
D. Rudman
semanticscholar   +1 more source

A possible role for cyclic guanosine monophosphate in the rat pineal gland

Neuroscience Letters, 1990
Adrenergic stimulation of pinealocytes induces an increase of both cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). However, for cGMP no biological effects have been demonstrated so far. Therefore we tested the effects of the analog 8-bromo-cGMP on synaptic ribbon numbers and on melatonin synthesis as reflected by N ...
A. Seidel, A Kantarjian, Lutz Vollrath
openaire   +3 more sources

Antagonists of excitatory amino acids and cyclic guanosine monophosphate in cerebellum

Neuropharmacology, 1982
The excitatory amino acid analogues kainate, quisqualate, domoic acid, 4-fluoroglutamate, homocysteic acid and N-methylaspartate as well as the tremor-inducing drugs harmaline and oxotremorine all induced significant elevations in cyclic guanosine monophosphate (cGMP) levels in the cerebellum in vivo. The putative antagonists of excitatory amino acids,
N. P. V. Nair, J.W. Richard, C. Pilapil, Paul L. Wood   +3 more
openaire   +3 more sources

Cyclic guanosine-3??5?-monophosphate induced diuresis in rats

Naunyn-Schmiedeberg's Archives of Pharmacology, 1974
In excretion studies in dogs it was found that cyclic guanosine-3′∶5′-monophosphate (cGMP) was eliminated by glomerular filtration only. If there is any permeability of the tubule cells to exogenous cGMP, it must be very low. cGMP (5×10−5 moles) injected into the thoracic aorta of rats induced an increase of the renal electrolyte excretion.
H. Osswald, O. Jacobs
openaire   +3 more sources

Insulin-like growth factor-1 restores erectile function in aged rats: modulation the integrity of smooth muscle and nitric oxide-cyclic guanosine monophosphate signaling activity.

Journal of Sexual Medicine, 2008
INTRODUCTION Insulin-like growth factor-1 (IGF-1) is one of the growth factors that have a wide range of biologic effects. We have confirmed that gene transfer of IGF-1 to the penis could improve erectile capacity.
X. Pu, Xing-huan Wang, W. Gao, Zhong‐Hua Yang, Shi-lin Li, Huai-peng Wang, Yi-long Wu   +6 more
semanticscholar   +1 more source

Cyclic guanosine monophosphate signalling pathway in pulmonary arterial hypertension

Vascular Pharmacology, 2013
During the last decade, it emerged that cyclic guanosine monophosphate (cGMP) is a novel drug target for the treatment of pulmonary arterial hypertension (PAH). cGMP regulates many cellular functions, ranging from contractility to growth, of relevance to the disease.
Lan Zhao, Geoffrey Watson, Chien-Nien Chen   +2 more
openaire   +3 more sources

Is cyclic guanosine monophosphate the internal 'second messenger' for cholinergic actions on central neurons?

Canadian Journal of Physiology and Pharmacology, 1976
The most consistent effects produced by intracellular injections of guanosine 3',5'-cyclic monophosphate (cGMP) (but not 5'-guanosine 5'-monophosphate in spinal motoneurons of cats are a rise in membrane conductance, acceleration in time course of spike ...
K. Krnjević, E. Puil, R. Werman
semanticscholar   +1 more source

Targeting Cyclic Guanosine Monophosphate to Treat Heart Failure: JACC Review Topic of the Week.

Journal of the American College of Cardiology, 2020
M. Emdin, A. Aimo, V. Castiglione, G. Vergaro, G. Georgiopoulos, Luigi Francesco Saccaro, C. Lombardi, C. Passino, E. Cerbai, M. Metra, M. Senni   +10 more
semanticscholar   +1 more source

Stimulation of polypeptide synthesis by cyclic 3′-5′-guanosine monophosphate

Archives of Biochemistry and Biophysics, 1973
Abstract 3′-5′-Cyclic GMP was found to stimulate polyphenylalanine synthesis in a cell-free system derived from rat liver. The effect of cyclic GMP is detected either in the presence or absence of GTP and appears quite specific since it is not produced by other cyclic nucleotides.
Vincenzo Macchia, Roberto Di Lauro, S. Varrone   +2 more
openaire   +3 more sources

A Raman and NMR structural characterization of cyclic guanosine monophosphate

1999
A molecular structure — biological function relationship has to exist for cyclic nucleotides (cGMP and cAMP) which are at the basis of important biochemical events (i. e. second messengers according to the Sutherland’s hypothesis).
Vitaliano Tugnoli, Giancarlo Fini, M. R. Tosi, Alessandro Bertoluzza, Anna Tinti   +4 more
openaire   +2 more sources