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Cyclic Nucleotide Phosphodiesterases
2000In multicellular organisms, cell functions are integrated through a large network of signals and homeostatic mechanisms that control the intracellular concentration of second messengers. This is a feature indispensable for the basal functions of the body, as well as for an efficient response to the continuous changes in the environment to which the ...
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Analysis of cyclic nucleotide phosphodiesterase(s) by radioimmunoassay
Archives of Biochemistry and Biophysics, 1982Abstract A high-affinity form of cyclic AMP phosphodiesterase, purified to apparent homogeneity from dog kidney, was labeled with 125 I using a solid-state lactoperoxidaseglucose oxidase system and its purity confirmed by acrylamide gel electrophoresis and isoelectric focusing.
Kolachana Sarada +3 more
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Identification and Characterization of Cyclic Nucleotide Phosphodiesterases
2013Cyclic nucleotide phosphodiesterases regulate cellular levels of small molecule second messengers that control important biological processes in all kingdoms of life. Identifying and characterizing these enzymes is necessary for basic research and pharmaceutical applications.
Erin B. Purcell, Rita Tamayo
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Cyclic Nucleotide Phosphodiesterases
2007Cyclic nucleotide phosphodiesterases (PDEs) are a family of enzymes that function to terminate the action of the hormone …
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Experimental Cell Research, 1979
Abstract Polysphondylium violaceum is shown to produce and excrete cyclic nucleotides and to produce a cell-associated cyclic nucleotide phosphodiesterase(s). The amount of adenosine 3′,5′-cyclic monophosphate (cAMP) excreted by the amebae reaches a maximum during development when aggregation centers are just forming and then falls off rapidly ...
Michael H. Hanna +2 more
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Abstract Polysphondylium violaceum is shown to produce and excrete cyclic nucleotides and to produce a cell-associated cyclic nucleotide phosphodiesterase(s). The amount of adenosine 3′,5′-cyclic monophosphate (cAMP) excreted by the amebae reaches a maximum during development when aggregation centers are just forming and then falls off rapidly ...
Michael H. Hanna +2 more
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Cyclic nucleotides, cyclic nucleotide phosphodiesterase, and development in Myxococcus xanthus
Canadian Journal of Microbiology, 1978Exogenous cyclic nucleotide phosphodiesterase (PD) accelerated fruiting body (FB) formation and increased territory size of aggregates in Myxococcus xanthus. Both guanosine 3′5′- monophosphate (cGMP) and guanosine 5′-monophosphate (GMP) were antagonistic to the PD effect.
W. J. Dobson, J. Ho, H. D. McCurdy
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Effects of lipids on cyclic-nucleotide phosphodiesterases
Biochemical and Biophysical Research Communications, 1973Abstract Several naturally-occurring lipids but not n-propanol, guanidine-HCl or a variety of synthetic detergents stimulate the 3′,5′-cyclic AMP-phosphodiesterase activities of a supernatant fraction of brain at 1.25 × 10 −7 M cAMP. The time courses of the reaction are linear in the presence and absence of lipid.
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Cyclic nucleotide phosphodiesterases as therapeutic targets in cardiac hypertrophy and heart failure
Nature Reviews Cardiology, 2022Rima Kamel +3 more
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Platelet Cyclic Nucleotide Phosphodiesterases
1999Currently, the two antiplatelet agents with proven efficacy are aspirin, which inhibits cyclooxygenase-dependent synthesis of thromboxane A2 (TXA2 ), and ticlopidine, which blocks the ability of ADP to inhibit stimulated adenyl cyclase. Both of these drugs have proven prophylactic uses in reducing the risk of thromboocclusive and thromboembolic ...
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Role of cyclic nucleotide phosphodiesterases in ischemic preconditioning
Molecular and Cellular Biochemistry, 1998Several signal transduction pathways have been implicated in the mechanism of protection induced by ischemic preconditioning (PC). For example, stimulation of a variety of G-protein coupled receptors results in stimulation of protein kinase C (PKC) which has been suggested to act as common denominator in eliciting protection.
Lochner A. +6 more
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