Results 61 to 70 of about 18,037,673 (136)

Temporal Mapping of CSVD‐Related White Matter Lesions and Concurrent Neurovascular Dysfunction in Spontaneously Hypertensive Rats

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
Hypertension induces early neurovascular dysfunction of CSVD, with white matter lesion onset at 28 weeks of age and progression to behavior deficits at 36 weeks of age in spontaneously hypertensive rats. Pde10a/cAMP signaling dysregulation may be related to this process and represent a potential therapeutic target.
Jing Peng, Jingnian Ni, Fuyao Li, Ting Li, Mingqing Wei, Tianci Ge, Lulu Yao, Jing Shi, Jinzhou Tian   +8 more
wiley   +1 more source

Phosphodiesterases, 3\u27,5\u27-cyclic nucleotide (PDEs) (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database [PDF]

, 2019
3\u27,5\u27-Cyclic nucleotide phosphodiesterases (PDEs, 3\u27,5\u27-cyclic-nucleotide 5\u27-nucleotidohydrolase), E.C. 3.1.4.17, catalyse the hydrolysis of a 3\u27,5\u27-cyclic nucleotide (usually cyclic AMP or cyclic GMP).
Yan, Chen
core   +1 more source

Nitric Oxide in Cancer: Mechanisms, Dual Role, and Therapeutic Strategies

MedComm – Oncology, Volume 5, Issue 3, September 2026.
Nitric oxide exerts concentration‐dependent dual roles in cancer, functioning as either a tumor promoter or suppressor. This review comprehensively examines NO's multifaceted regulation of tumor biology, including S‐nitrosylation signaling, metabolic reprogramming, immunemodulation, and therapy resistance, and highlights emerging therapeutic strategies
Jia Shao, Honghua Zhang, Jingyu Chen, Ziyu Qian, Ning Zhang, Yihua Zhang, Hui Ye, Jianbing Wu, Zhangjian Huang   +8 more
wiley   +1 more source

Cyclic Nucleotide Binding GAF Domains from Phosphodiesterases: Structural and Mechanistic Insights [PDF]

, 2009
GAF domains regulate the catalytic activity of certain vertebrate cyclic nucleotide phosphodiesterases (PDEs) by allosteric, noncatalytic binding of cyclic nucleotides.
Pandit, Jayvardhan, Heikaus, Clemens C., Klevit, Rachel E.   +2 more
core   +1 more source

Molecular logics in dual sensor regulation of diguanylate cyclase activity—Phosphorylation OR blue‐light activation

Protein Science, Volume 35, Issue 9, September 2026.
Abstract Bacterial cells use multiple environmental cues to regulate levels of the second messenger cyclic dimeric GMP. This compound influences key lifestyle decisions such as motility, biofilm formation, or virulence. Although many diguanylate cyclases (DGCs) combined with various sensory domains have been studied previously, how distinct inputs are ...
Maximilian Fuchs, Andreas Winkler
wiley   +1 more source

The selective degradation of PDE4B shortform, using a PROTAC, leads to inhibition of several hallmarks of cancer in HCT116 cells

British Journal of Pharmacology, Volume 183, Issue 18, Page 5516-5540, September 2026.
Background and Purpose Colorectal cancer is one of the most prevalent cancers worldwide, and novel precision medicine approaches are rapidly improving patient outcomes. Phosphodiesterase 4B (PDE4B) is a member of an enzyme family (PDE4) that hydrolyses intracellular cAMP to control spatial and temporal signalling cues.
Alina Zorn, John Daniel Pediani, Madihah Hussain, Jiayue Ling, Elaine Brown, Igor Belka, Eduardo Torres, Cathy Swindlehurst, Kyle Chan, David Stirling, George S. Baillie, Yuan Yan Sin   +11 more
wiley   +1 more source

Characterization of cyclic nucleotide phosphodiesterase isoenzymes in the human ureter and their functional role in vitro [PDF]

, 1994
Meyer, M. F., Schulz-Knappe, P., Forssmann, W. G., Stief, Christian Georg, Taher, A., Jonas, Udo, Truss, Michael C., C.G. Stief, A. Taher, P. Schulz-Knappe, M. Meyer, U. Jonas, M. Truss, W.-G. Forssmann   +13 more
core   +1 more source

The WHO Classification of Genetic Tumour Syndromes: Considerations for Genetics

Clinical Genetics, Volume 110, Issue 3, Page 389-401, September 2026.
The WHO Classification of Tumours underpins the diagnosis of neoplastic conditions. The new WHO classification of genetic tumour syndromes (GTS) provides international standards for their diagnosis. This diagram highlights the chromosomal distribution of the genes involved in the GTS covered in this classification.
Ian A. Cree, Mark J. Arends, Joseph D. Khoury, Erika R. E. Denton, Anthony J. Gill, Alexander J. Lazar, Ian M. Frayling, Stefan M. Pfister, Mark A. Rubin, Katia R. M. Leite, Raymond Dalgleish, Elspeth A. Bruford, Sharon E. Plon, Ada Hamosh, Michael Francis Walsh, Gabrielle Goldman‐Lévy, Harshima Wijesinghe, William D. Foulkes, Dilani Lokuhetty   +18 more
wiley   +1 more source

Phosphodiesterases, 3\u27,5\u27-cyclic nucleotide (PDEs) in GtoPdb v.2025.1

3\u27,5\u27-Cyclic nucleotide phosphodiesterases (PDEs, 3\u27,5\u27-cyclic-nucleotide 5\u27-nucleotidohydrolase), E.C. 3.1.4.17, catalyse the hydrolysis of a 3\u27,5\u27-cyclic nucleotide (usually cyclic AMP or cyclic GMP).
Yan, Chen
core   +1 more source

Family-Wide Dysregulation of Phosphodiesterases Alters cAMP/cGMP Microdomains in Thoracic Aortic Aneurysm. [PDF]

J Cardiovasc Dev Dis
Magouliotis DE, Sicouri S, Androutsopoulou V, Baudo M, Cabrucci F, Zotos PA, Xanthopoulos A, Ramlawi B.   +7 more
europepmc   +1 more source