Results 61 to 70 of about 12,602 (147)

THE CONCISE GUIDE TO PHARMACOLOGY 2017/18:Enzymes [PDF]

, 2017
The Concise Guide to PHARMACOLOGY 2017/18 provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access knowledgebase of drug targets and ...
,, Alexander, Stephen Ph, Davies, Jamie A, Fabbro, Doriano, Faccenda, Elena, Harding, Simon D, Kelly, Eamonn, Marrion, Neil V, Pawson, Adam J, Peters, John A, Sharman, Joanna L, Southan, Christopher   +11 more
core   +15 more sources

Why Is MS a More Frequent Complication of EBV Infection in Females?

Immunological Reviews, Volume 339, Issue 1, May 2026.
ABSTRACT Multiple sclerosis (MS) is a T helper (Th) cell‐mediated disease that targets central nervous system (CNS) white matter. This disease affects three times more females than males. For many years, the etiology of MS was not well understood and the exact nature of the autoimmune reaction was speculative.
Shannon E. Dunn, Nuria Alvarez‐Sanchez, Lawrence Steinman   +2 more
wiley   +1 more source

PDE8 controls CD4(+) T cell motility through the PDE8A-Raf-1 kinase signaling complex [PDF]

, 2017
The levels of cAMP are regulated by phosphodiesterase enzymes (PDEs), which are targets for the treatment of inflammatory disorders. We have previously shown that PDE8 regulates T cell motility.
Baillie, George S., Basole, Chaitali P., Brocke, Stefan, Clark, Robert, Epstein, Paul M, Lamothe, Katie, Nguyen, Rebecca K., Vang, Amanda   +7 more
core   +1 more source

Untargeted Metabolomic and Lipidomic Profiles of Gingival Crevicular Fluid in the Context of Periodontitis

Journal of Clinical Periodontology, Volume 53, Issue 5, Page 774-783, May 2026.
ABSTRACT Aim(s) This cross‐sectional clinical study aimed to explore the untargeted metabolomic and lipidomic profiles in gingival crevicular fluid (GCF) obtained from healthy individuals and patients with periodontitis. Materials and Methods GCF was collected from 17 periodontally healthy and 19 periodontitis patients.
Caroline H. Henderzahs, Chiaki Yamada, Alexandr Morozov, Thelmalane Yalartai, Vanchit John, Hawra AlQallaf, Alexandru Movila   +6 more
wiley   +1 more source

Cyclic nucleotide specificity of the activator and catalytic sites of a cGMP-stimulated cGMP phosphodiesterase from Dictyostelium discoideum [PDF]

, 1985
The cellular slime mold Dictyostelium discoideum has an intracellular phosphodiesterase which specifically hydrolyzes cGMP. The enzyme is activated by low cGMP concentrations, and is involved in the reduction of chemoattractant-mediated elevations of ...
Baraniak, Janina,, Bulgakov, Roman,, Haastert, Peter J.M. van,, Jastorff, Bernd,, Kesbeke, Fanja,, Morr, Michael,, Petridis, Georg,, Seela, Frank,, Stec, Wojciech J.,   +8 more
core   +2 more sources

Dysregulation of CD39/Ectonucleoside Triphosphate Diphosphohydrolase 1 Causes Urinary Bladder Dysfunction with Abnormal Smooth Muscle Contractility

The FASEB Journal, Volume 40, Issue 7, 15 April 2026.
Abnormal extracellular ATP levels cause lower urinary tract symptoms (LUTS). Here, we demonstrate that overexpression of ENTPD1 (CD39TG)—an ATP/ADP converting enzyme—reduces voiding frequency while increasing void volume. Conversely, ENTPD1 deficiency results in frequent, small‐volume voiding.
Zhaobo Luo, Huan Chen, Ali Wu, Weipu Mao, Sagar Barge, Seth L. Alper, Simon C. Robson, Weiqun Yu   +7 more
wiley   +1 more source

Activity of Cyclic AMP Phosphodiesterases and Adenylyl Cyclase in Peripheral Nerve after Crush and Permanent Transection Injuries [PDF]

, 1998
Recent studies demonstrate that cAMP levels are tightly controlled during demyelination and remyelination in Schwann cells as cAMP decreases to 8–10% of normal following both sciatic nerve crush or permanent transection injury and only begins to increase
Poduslo, Joseph F., Walikonis, Randall S.   +1 more
core   +1 more source

Pharmacological Validation of Trypanosoma brucei Phosphodiesterases as Novel Drug Targets [PDF]

, 2017
The development of drugs for neglected infectious diseases often uses parasite-specific enzymes as targets. We here demonstrate that parasite enzymes with highly conserved human homologs may represent a promising reservoir of new potential drug targets ...
de Koning, Harry P., Gould, Matthew K., Kunz, Stefan, Luginbuehl, Edith, Seebeck, Thomas, Sterk, Geert Jan, Tenor, Hermann   +6 more
core  

Synergy between 5-HT4 receptor stimulation and phosphodiesterase 4 inhibition in facilitating acetylcholine release in human large intestinal circular muscle

, 2018
Background: Gastroprokinetic properties of 5-HT4 receptor agonists, such as prucalopride, are attributed to activation of 5-HT4 receptors on cholinergic nerves innervating smooth muscle in the gastrointestinal smooth muscle layer, increasing ...
Afzal, Alexander, Beavo, Bouras, Broad, Broad, Broad, Camilleri, Campbell-Dittmeyer, Cellek, Cellek, Chen, Craig, Elks, Emmanuel, Emmanuel, Galindo-Tovar, Galligan, Gershon, Hagiwara, Hidaka, Jones, Keating, Krobert, Leclere, Leclere, Lefebvre, Lefebvre, Loughney, Maeyer, Maeyer, Maeyer, Maurice, McLean, Michalski, Michie, O'Grady, Parker, Podzuweit, Priem, Priem, Priem, Prins, Prins, Rabe, Saeki, Sloots, Smith, Sudo, Tonini, Tralau-Stewart, Wan, Wang, Weninger, Yuan   +54 more
core   +1 more source

Characterization of cyclic nucleotide phosphodiesterase isoenzymes in the human ureter and their functional role in vitro [PDF]

, 1994
Forssmann, W. G., Jonas, Udo, Meyer, M. F., Schulz-Knappe, P., Stief, Christian Georg, Taher, A., Truss, Michael C.   +6 more
core   +1 more source