Results 91 to 100 of about 7,638 (298)
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Cyclic Partitions of Complete and Almost Complete Uniform Hypergraphs
Discussiones Mathematicae Graph Theory, 2022 We consider cyclic partitions of the complete k-uniform hypergraph on a finite set V, minus a set of s edges, s ≥ 0. An s-almost t-complementary k-hypergraph is a k-uniform hypergraph with vertex set V and edge set E for which there exists a permutation ...
Dilbarjot, Gosselin Shonda Dueck
doaj +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Permutation orbifolds and holography [PDF]
, 2015 : Two dimensional conformal field theories with large central charge and a sparse low-lying spectrum are expected to admit a classical string holographic dual. We construct a large class of such theories employing permutation orbifold technology.
Rangamani, Mukund +5 more
core +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
From Product Codes to Structured Generalized LDPC Codes [PDF]
, 2010 Product codes, due to their relatively large minimum distance, are often seen as a natural solution for applications requiring low error floors.
Paolini, Enrico +10 more
core +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
The q-ary image of some qm-ary cyclic codes: permutation group and soft-decision decoding [PDF]
, 2002 Using a particular construction of generator matrices of the q-ary image of qm-ary cyclic codes, it is proved that some of these codes are invariant under the action of particular permutation groups.
Lacan, Jérôme, Delpeyroux, Emmanuelle
core +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source