Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Algebraic Theoretic Properties of the Non-associative Class of (132)-Avoiding Patterns of AUNU Permutations: Applications in the Generation and Analysis of a General Cyclic Code [PDF]
, 2016 Chun P. B, A. A. Ibrahim, Garba A.I
openalex +1 more source
Rational and Quasi-Permutation Representations of Holomorph of Cyclic p-Groups [PDF]
, 2021 Soham Swadhin Pradhan, B. Sury
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E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Cyclic permutations realized by signed shifts [PDF]
, 2014 Kassie Archer, Sergi Elizalde
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KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
κ-Lookback random-based text encryption technique
Journal of King Saud University: Computer and Information Sciences, 2019 Although many encryption methods are available, there is always an ongoing need for more to resist the adversaries’ ever-growing analytical skills and techniques. We propose in this paper an innovative method for text encryption.
Muhammed J. Al-Muhammed, Raed Abu Zitar
doaj +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Quasi-cyclic extension based on PEG algorithm for construction of LDPC codes
Tongxin xuebao, 2008 Several important relations between the cycle structure on the Tanner graph and the parity-check matrix H of LDPC codes were proved.A new algorithm for constructing LDPC codes was proposed that introduced quasi-cyclic ex-tension method to PEG algorithm ...
LEI Jing1 +2 more
doaj +2 more sources