Results 141 to 150 of about 37,653 (292)

Research and Implementation of Secure Upgrade Method for Embedded Control Software

open access: yesKongzhi Yu Xinxi Jishu
In order to respond to challenges encountered in the software upgrade of embedded systems due to frequent demand changes and technological iterations, this paper presents the design of a secure software upgrade methodology and process.
CHEN Junbo, ZOU Junyang, ZHANG Tianyu
doaj  

Systematic Engineering of Proteases in Saccharopolyspora Spinosa Reveals Synergistic Enhancement of Spinosad Biosynthesis via Substrate Flux Optimization

open access: yesAdvanced Science, EarlyView.
ARTP mutagenesis yielded Saccharopolyspora spinosa mutant D184 with improved extracellular nitrogen utilization. An integrated workflow of protease genetic manipulation, multi‐omics, and rational synergy design pinpointed a pepP‐clpP‐htpX synergistic triangular combination.
Duo Jin   +9 more
wiley   +1 more source

Generative AI‐Driven Accelerated Discovery of Passivation Molecules for Perovskite Solar Cells

open access: yesAdvanced Science, EarlyView.
A generative artificial intelligence (AI) framework combining a discriminative machine learning model (SMILES‐X) and a generative language model (GPT‐2) autonomously discovers new molecular passivators for perovskite solar cells (PSCs). Through an iterative design loop, over 100 000 candidates are generated and screened, and randomly selected molecules
Adroit T. N. Fajar   +7 more
wiley   +1 more source

Deciphering the Evolution Pattern of Structural Variations Overlapped With Repetitive Sequence During Cattle Evolution

open access: yesAdvanced Science, EarlyView.
The authors complement bovine pan‐SV with massive novel structural variations (SVs) identified through long‐read sequencing of 83 globally distributed cattle breeds. Repetitive sequence‐mediated SVs (rep‐SV) exhibit distinct dynamic patterns throughout cattle sub‐speciation and/or domestication processes, including uneven distribution between chr‐X and
Zhifan Guo   +16 more
wiley   +1 more source

Nuclear Mechanotransduction Across the Metastatic Cascade: Decoding Spatiotemporal Heterogeneity in Cancer Dissemination

open access: yesAdvanced Science, EarlyView.
Tumor metastasis results from complex interactions between cancer cells and mechanical microenvironments. We propose a “nucleus‐centered, cross‐stage mechanical signal decoding” model, highlighting how nuclear mechanosensors interpret forces at different stages.
Linqi Song   +4 more
wiley   +1 more source

Endometrial Epithelial Lactate Deficiency Drives CD8+ T‐Cells Dysregulation in Unexplained Recurrent Implantation Failure

open access: yesAdvanced Science, EarlyView.
Unexplained recurrent implantation failure (RIF) represents a significant clinical challenge. Our results demonstrate that reduced lactate production in the RIF endometrium impairs the suppression of cytotoxic CD8+ T‑cells, allowing their proliferation and thereby disrupting the local immune balance essential for successful embryo implantation.
Yuanlin He   +18 more
wiley   +1 more source

Discovering Interpretable Semantics from Radio Signals for Contactless Cardiac Monitoring

open access: yesAdvanced Science, EarlyView.
This study presents a semantic representation framework for clinically interpretable cardiac monitoring from contactless radio signals. It formulates radio semantic learning as an information‐bottleneck problem and approximates the objective via intra‐modal compression and cross‐modal alignment, structuring radio measurements into meaningful semantic ...
Jinbo Chen   +10 more
wiley   +1 more source

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