Results 51 to 60 of about 37,653 (292)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Fast Node Polar Decoding Method Based on Hybrid Parity Check and CRC

IEEE Access
In the case of short code, polar code demonstrates superior performance compared with Low Density Parity Check (LDPC) code. Particularly in low coding rate scenario, the complexity of Polar code encoding and decoding is significantly lower than that of ...
Zongmiao He, Yangjun Chen, Shipeng Gao, Cenyu Pei, Weijie Xia, Xiang Ling   +5 more
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Polar Codes With Repeating Bits and the Construction by Cluster Pairwise Error Probability

IEEE Access, 2019
A polar code with repeating bits (RB polar code), where a part of frozen bits only repeat their preceding information bits, is proposed. In the code construction, we propose cluster pairwise error probability (CPEP) to measure the competitiveness of the ...
Tao Wang, Daiming Qu, Tao Jiang
doaj   +1 more source

CRC-Aided Adaptive BP Decoding of PAC Codes

Entropy, 2022
Although long polar codes with successive cancellation decoding can asymptotically achieve channel capacity, the performance of short blocklength polar codes is far from optimal.
Xianwen Zhang, Ming Jiang, Mingyang Zhu, Kailin Liu, Chunming Zhao   +4 more
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Distance Properties of Short LDPC Codes and their Impact on the BP, ML and Near-ML Decoding Performance

, 2017
Parameters of LDPC codes, such as minimum distance, stopping distance, stopping redundancy, girth of the Tanner graph, and their influence on the frame error rate performance of the BP, ML and near-ML decoding over a BEC and an AWGN channel are studied ...
A Orlitsky, AS Asratian, C Di, CE Shannon, ER Berlekamp, G Poltyrev, H Pishro-Nik, H Pishro-Nik, I Sason, IE Bocharova, J Feldman, J Zumbrägel, M Baldi, M Jianjun, M Schwartz, N Varnica, RG Gallager, S Litsyn, T Hehn, T Richardson   +19 more
core   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

An improved path splitting strategy on successive cancellation list decoder for polar codes

IET Communications, 2021
The performance of the cyclic redundancy check aided successive cancellation list (CA‐SCL) decoder for polar codes exceeds that of the Turbo codes and the Low Density Parity Check (LDPC) codes adopted in the World Interoperability for Microwave Access ...
Yunlong Peng, Jingyun Bao, Xingcheng Liu
doaj   +1 more source

Telemetry problems with pacemakers in a noisy environment [PDF]

, 1985
This report covers the investigation of problems relating to the telemetry of pacemakers in a noisy environment. An attempt was made to suggest schemes that improve system performance.
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