Results 21 to 30 of about 157,043 (159)

Oncogene-induced DNA damage: cyclic AMP steps into the ring [PDF]

Journal of Clinical Investigation, 2020
Growth hormone-secreting (GH-secreting) pituitary tumors are driven by oncogenes that induce cAMP signaling. In this issue of the JCI, Ben-Shlomo et al. performed a whole-exome study of pituitary adenomas. GH-secreting tumors had a high frequency of whole chromosome or chromosome arm copy number alterations and were associated with an increase in the ...
James A, Fagin, John H, Petrini
openaire   +2 more sources

Structure and dynamics underlying elementary ligand binding events in human pacemaking channels

eLife, 2016
Although molecular recognition is crucial for cellular signaling, mechanistic studies have relied primarily on ensemble measures that average over and thereby obscure underlying steps. Single-molecule observations that resolve these steps are lacking due
Marcel P Goldschen-Ohm, Vadim A Klenchin, David S White, John B Cowgill, Qiang Cui, Randall H Goldsmith, Baron Chanda   +6 more
doaj   +1 more source

Experimental and Numerical Study of Cyclic Stress–Strain Response and Fatigue Crack Initiation Life of Mid-Carbon Steel under Constant and Multi-Step Amplitude Loading

Journal of Marine Science and Engineering, 2022
This paper investigates the fatigue cyclic deformation behavior of mid-carbon steel. Uniaxial tensile loading tests and fatigue tests under constant and multi-step amplitude loading steps are performed to characterize the influence of loading history ...
Kasumi Morita, Masashi Mouri, Riccardo Fincato, Seiichiro Tsutsumi   +3 more
doaj   +1 more source

Subunit promotion energies for channel opening in heterotetrameric olfactory CNG channels.

PLoS Computational Biology, 2022
Cyclic nucleotide-gated (CNG) ion channels of olfactory sensory neurons contain three types of homologue subunits, two CNGA2 subunits, one CNGA4 subunit and one CNGB1b subunit. Each subunit carries an intracellular cyclic nucleotide binding domain (CNBD)
Jana Schirmeyer, Thomas Eick, Eckhard Schulz, Sabine Hummert, Christian Sattler, Ralf Schmauder, Klaus Benndorf   +6 more
doaj   +1 more source

Iminoiodane- and Brønsted Base-Mediated Cross Dehydrogenative Coupling of Cyclic Ethers with 1,3-Dicarbonyl Compounds

Molecules, 2015
A one-pot, two-step approach to prepare 2-tetrahydrofuran and -pyran substituted 1,3-dicarbonyl compounds by PhI=NTs-mediated amination/Brønsted base-catalyzed cross dehydrogenative coupling (CDC) reaction of the cyclic ether and 1,3-dicarbonyl ...
Ciputra Tejo, Xiao Rong Sim, Bo Ra Lee, Benjamin James Ayers, Chung-Hang Leung, Dik-Lung Ma, Philip Wai Hong Chan   +6 more
doaj   +1 more source

Experimental investigation of changes in petrophysical properties and structural deformation of carbonate reservoirs

Petroleum Exploration and Development, 2019
To examine the effect of pressure on pore structure and petrophysical properties of carbonate rock, the porosity, permeability, CT scanning, SEM and elastic wave velocity of two carbonate core plug samples from an oilfield in Southwest Iran were analyzed
Yaser SALIMIDELSHAD, Ali MORADZADEH, Ezatallah KAZEMZADEH, Peyman POURAFSHARY, Abbas MAJDI   +4 more
doaj   +1 more source

Improved Convergence Speed of a DCD-Based Algorithm for Sparse Solutions

Algorithms, 2020
To solve a system of equations that needs few updates, such as sparse systems, the leading dichotomous coordinate descent (DCD) algorithm is better than the cyclic DCD algorithm because of its fast speed of convergence.
Zhi Quan, Shuhua Lv
doaj   +1 more source

Different types of cyclic steps nearby Manila Trench of northern South China Sea and analysis of forming mechanism

Frontiers in Marine Science
High-resolution multibeam bathymetric enables detailed morphological investigation of the area of Manila Trench on the northeastern South China Sea margin, where twenty-three cyclic steps are observed.
Yuping Yang, Yuping Yang, Shuwei Zhang, Shuwei Zhang, Shuang Li, Kaiqi Yu, Kaiqi Yu, Xuesheng Qian, Xuesheng Qian, Xuesheng Qian, Chenghao Wang, Jingping Xu   +11 more
doaj   +1 more source

Large‐Scale Submarine Sediment Waves at Macauley Caldera Volcano: In Situ Evidence of High‐Flux, Syn‐Eruptive Submarine Transport

Geochemistry, Geophysics, Geosystems
Two sediment cores were collected from a submarine sediment wave field on the flank of Macauley volcano. Combined with seismic reflection surveys and numerical modeling, we present an integrated model of the formation of large‐scale, eruption‐fed ...
Shannon E. Frey, Martin Jutzeler, Matthieu Cartigny, Rebecca J. Carey   +3 more
doaj   +1 more source

Mechanistic insight into the conserved allosteric regulation of periplasmic proteolysis by the signaling molecule cyclic-di-GMP

eLife, 2014
Stable surface adhesion of cells is one of the early pivotal steps in bacterial biofilm formation, a prevalent adaptation strategy in response to changing environments.
Debashree Chatterjee, Richard B Cooley, Chelsea D Boyd, Ryan A Mehl, George A O'Toole, Holger Sondermann   +5 more
doaj   +1 more source