Results 61 to 70 of about 523,816 (270)
Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
Journal of Lipid Research, 1973 Isolated rat hepatocytes rapidly utilized [14C] palmitate and, in particular, synthesized large amounts of neutral lipids from palmitate. Incorporation into cellular lipids occurred at a linear rate proportional to the medium concentration of fatty acids.
Charles J. Homcy, Simeon Margolis
doaj +1 more source
Improving the smoothed complexity of FLIP for max cut problems
, 2018 Finding locally optimal solutions for max-cut and max-$k$-cut are well-known PLS-complete problems. An instinctive approach to finding such a locally optimum solution is the FLIP method. Even though FLIP requires exponential time in worst-case instances,
Bibak, Ali +2 more
core +1 more source
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
WEIGHTED Decoding of Cyclic codes using quantized SIGNAL DEMODULATOR on PM signals
Доклады Белорусского государственного университета информатики и радиоэлектроники, 2019 A weighted iterative majority-logic decoding algorithm of cyclic codes with soft (quantized) detections of Phase-Modulating (PM) signals is analyzed. Evaluation of the correction capability of the algorithm on cyclic codes with quantization of PM signals
N. A. Salas +2 more
doaj
Cyclic Block Copolymer Microchannel Fabrication and Sealing for Microfluidics Applications
Inventions, 2018 High mechanical rigidity, chemical resistance, and ultraviolet-visible light transmissivity of thermoplastics are attractive characteristics in microfluidics because various biomedical microfluidic devices require solvent, acid, or base manipulation, and
Chia-Yi Yen +4 more
doaj +1 more source
Two-Step Signal Detection for MIMO-OFDM Systems without Cyclic Prefix [PDF]
2009 IEEE Wireless Communications and Networking Conference, 2009 In this paper, a MIMO-OFDM system without cyclic prefix (CP) is considered and a two-step signal detection algorithm is proposed. The algorithm is based on some structural properties derived from shifting the received OFDM symbols. The first step cancels inter-carrier interference (ICI) and inter-symbol interference (ISI) with an equalizer designed ...
Ng, TS, Ma, S
openaire +2 more sources
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source