Results 71 to 80 of about 523,816 (270)
The Cyclicality of the Stepping-Stone Effect of Temporary Agency Employment [PDF]
SSRN Electronic Journal, 2018 This paper investigates whether the stepping stone effect of temporary agency employment moves over the business cycle. Using German administrative data for the period 1985-2012 and an estimation framework based on the timing-events model, we construct a time series of in-treatment and post-treatment effects and estimate their relationship to the ...
Jahn, Elke J., Rosholm, Michael
openaire +3 more sources
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
A streamlined protocol for the detection of mRNA–sRNA interactions using AMT-crosslinking in vitro
BioTechniques, 2019 Until recently, RNA–RNA interactions were mainly identified by crosslinking RNAs with interacting proteins, RNA proximity ligation and deep sequencing. Recently, AMT-based direct RNA crosslinking was established.
Rebecca Kirsch +6 more
doaj +1 more source
FEBS Letters, EarlyView.Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley +1 more source
Voltammetric study of new psychoactive substance 3‐fluorophenmetrazine
Electrochemical Science Advances, 2023 Electrochemical oxidation of the new psychoactive substance 3‐fluorophenmetrazine (FPM) was studied in phosphate buffers by cyclic voltammetry and differential pulse voltammetry (DPV) on a glassy carbon electrode.
Eliška Jiroušková +2 more
doaj +1 more source
Spectral and Dynamical Properties in Classes of Sparse Networks with Mesoscopic Inhomogeneities
, 2009 We study structure, eigenvalue spectra and diffusion dynamics in a wide class of networks with subgraphs (modules) at mesoscopic scale. The networks are grown within the model with three parameters controlling the number of modules, their internal ...
A. Banerjee +8 more
core +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
On improving the iterative convergence properties of an implicit approximate-factorization finite difference algorithm [PDF]
The iterative convergence properties of an approximate-factorization implicit finite-difference algorithm are analyzed both theoretically and numerically.
Desideri, J. A. +2 more
core +1 more source
Chemoenzymatic Synthesis of Cryptophycin Anticancer Agents by an Ester Bond-Forming Non-ribosomal Peptide Synthetase Module [PDF]
, 2011 Cryptophycins (Crp) are a group of cyanobacterial depsipeptides with activity against drug-resistant tumors. Although they have been shown to be promising, further efforts are required to return these highly potent compounds to the clinic through a new ...
Bolduc, Kyle L. +4 more
core +1 more source