Results 81 to 90 of about 523,816 (270)

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Sample Testing with Vitalab Flexor [PDF]

, 2000
The Vitalab Flexor is a high-tech medical instrument designed to perform a large number of simultaneous measurements on samples of blood and urine. For future purposes it is desired to increase the throughput, i.e.
Baas, S., Hurink, J.
core  

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Self-organizing patterns maintained by competing associations in a six-species predator-prey model

, 2008
Formation and competition of associations are studied in a six-species ecological model where each species has two predators and two prey. Each site of a square lattice is occupied by an individual belonging to one of the six species.
Attila Szolnoki, György Szabó, István Borsos, M. E. Gilpin, M. Eigen   +4 more
core   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

The first preparative solution phase synthesis of melanotan II

Beilstein Journal of Organic Chemistry, 2008
Melanotan II is a synthetic cyclic heptapeptide used to prevent a sunlight-induced skin cancer by stimulating the skin tanning process. In this paper we report the first solution phase synthesis of the title compound.
Vladimir V. Ryakhovsky, Georgy A. Khachiyan, Nina F. Kosovova, Elena F. Isamiddinova, Andrey S. Ivanov   +4 more
doaj   +1 more source

Iron-Binding and Anti-Fenton Properties of Novel Amino Acid-Derived Cyclic Imide Dioximes

Antioxidants, 2019
We present a novel route for the preparation of amino acid-derived cyclic imide dioxime derivatives. Readily accessible amino acids were conveniently converted to their corresponding cyclic imide dioximes in simple synthetic steps.
Janez Mravljak, Žiga Jakopin
doaj   +1 more source

A Computation in a Cellular Automaton Collider Rule 110

, 2016
A cellular automaton collider is a finite state machine build of rings of one-dimensional cellular automata. We show how a computation can be performed on the collider by exploiting interactions between gliders (particles, localisations).
A Adamatzky, A Adamatzky, A Bandyopadhyay, A Wuensche, AC Scott, AJ Heeger, AR Smith III, AS Davydov, B Grünbaum, EF Codd, GJ Martínez, GJ Martínez, GJ Martínez, GJ Martínez, GJ Martínez, GJ Martínez, GJ Martínez, HV McIntosh, JL Bredas, JW Mills, K Lindgren, K Morita, K Morita, M Cook, M Kudlek, M Kudlek, MA Arbib, MH Jakubowski, N Margolus, NH Margolus, NH Margolus, S Ninagawa, S Siccardi, S Wolfram, S Wolfram, T Neary, T Toffoli, Y Lu   +37 more
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Pressure swing adsorption process modeling using physics-informed machine learning with transfer learning and labeled data

Green Chemical Engineering
Pressure swing adsorption (PSA) modeling remains a challenging task since it exhibits strong dynamic and cyclic behavior. This study presents a systematic physics-informed machine learning method that integrates transfer learning and labeled data to ...
Zhiqiang Wu, Yunquan Chen, Bingjian Zhang, Jingzheng Ren, Qinglin Chen, Huan Wang, Chang He   +6 more
doaj   +1 more source