Results 181 to 190 of about 904,141 (304)

Direct C1-H Amination of Free NH Carbazoles Enabled by the Catellani Reaction. [PDF]

Org Lett
Sorabad GS, Mazzeo PP, Motti E, Della Ca' N.   +3 more
europepmc   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Mechanochemical C-C bond stability as a function of substitution: a computational and experimental study. [PDF]

RSC Adv
Gouli O, Zhang H, Ivry E, Aggarwal K, Diesendruck CE.   +4 more
europepmc   +1 more source

Fluorination: A strategy to tune the interactions of molecules and nanoscale systems with biological matter

FEBS Open Bio, EarlyView.
This minireview explores fluorination as a key strategy to optimize therapeutic molecules and nanocarriers. By incorporating different fluorinated motifs—from single atoms to linear and branched chains—drug delivery, cellular uptake, and colloidal stability can be improved and fine‐tuned.
Martina Beccalli, Beatrice Lucia Bona, Francesca Baldelli Bombelli   +2 more
wiley   +1 more source

The Coalescence of a "Happy Accident" and an In Vitro Structure-Activity Panel: Increasing the Potency of a Cyclic Peptide Inhibitor to Thrombosis Initiation. [PDF]

ChemMedChem
Barreto GM, Wixted B, Kouba CM, Riordan JA, Tonks C, David R, Oldfield AL, Lisojo A, Guarracino DA.   +8 more
europepmc   +1 more source

A nationwide student survey on biochemistry learning resources in Italy

FEBS Open Bio, EarlyView.
We conducted a survey among Italian university students to investigate their preferred study materials for biochemistry. We then analyzed the collected data to identify these materials. This information may be valuable to the Biochemistry educational community. The graphical abstract was created with Claude (Opus 5.5; Anthropic, 2026).
Anna Marabotti, Ivano Eberini, Maria Luisa Genova, Francesca Mensitieri, Francesco Malatesta   +4 more
wiley   +1 more source

Counter-cyclical substitution between trade credit and bank credit

This paper explores the substitution relationship between trade credit and bank credit, and its counter-cyclic dynamic pattern through economic cycles. We propose a new theoretical model, using a mechanism design method, which predicts the substitution ...
Huang, Hui, Shi, Xiaojun, Zhang, Shunming   +2 more
core  

Cyclic sulfone ring remodeling enables molecular shape diversity-oriented synthesis of privileged biaryl and oligoaryl motifs. [PDF]

Nat Commun
Nguyen VD, Nand S, Trevino R, Porey A, Thompson WT, Haug GC, Fremin SO, Dhakal SK, Hughes WB, Moran DP, Lakey-Beitia J, Giri CK, Manning-Lorino P, Greco SG, Arman HD, Larionov OV.   +15 more
europepmc   +1 more source

Hydrogel platforms for 3D cardiac tissue engineering and fibrotic disease modelling

FEBS Open Bio, EarlyView.
Hydrogel‐based cardiac tissue models are advancing our understanding of heart health and disease. By incorporating electrical conductivity, aligned structures, and tunable mechanical properties, these platforms better replicate the complex environment of native heart tissue.
Harrison Porritt, Annika Winbo, Jenny Malmström   +2 more
wiley   +1 more source

Aryne-mediated direct assembly of <i>O</i>-bridged seven-membered cyclic diaryliodoniums: access to oxaheteropines and cannabinols <i>via</i> skeletal modification. [PDF]

Chem Sci
Kamioka S, Morohashi S, Kikuchi J, Kwon E, Yoshikai N.   +4 more
europepmc   +1 more source