Results 351 to 360 of about 504,196 (405)

Functional Evolution of Cyclin-Dependent Kinases

Molecular Biotechnology, 2009
Cyclin-dependent kinases (CDKs) are serine/threonine protein kinases with a well established role in the regulation of the eukaryotic cell cycle. Recent studies with animal cells have implicated CDK activity in additional diverse cellular processes, including transcription, translation and mRNA processing.
John H. Doonan, Georgios Kitsios
openaire   +3 more sources

p27KIP1, an inhibitor of cyclin-dependent kinases

1995
The identification of a family of proteins that stoichiometrically regulate the activation of the G1 cyclin-dependent kinases has added to our understanding of the process of commitment to the mitotic cycle. The properties of p27 as a CDK binding protein, the ability of environmental signals to regulate the expression of p27, and the observation that ...
Kornelia Polyak, Andrew Koff
openaire   +3 more sources

Dissecting the Determinants of Cyclin-Dependent Kinase 2 and Cyclin-Dependent Kinase 4 Inhibitor Selectivity

Journal of Medicinal Chemistry, 2006
Cyclin dependent kinases are a key family of kinases involved in cell cycle regulation and are an attractive target for cancer chemotherapy. The roles of four residues of the cyclin-dependent kinase active site in inhibitor selectivity were investigated by producing cyclin-dependent kinase 2 mutants bearing equivalent cyclin-dependent kinase 4 residues,
Pratt DJ, Bentley J, Jewsbury P, Boyle FT, Endicott JA, Noble MEM   +5 more
openaire   +4 more sources

Cyclin-dependent kinases as targets for cancer therapy

Update on Cancer Therapeutics, 2003
Cell cycle perturbations are commonly observed in human malignancies. Exploiting this finding is the rationale for the development of CDK inhibitors as anti-tumor agents. Single-agent evaluation of several CDKIs has demonstrated limited clinical activity.
Gary K. Schwartz, Manish A. Shah
openaire   +5 more sources

Targets of cyclin-dependent protein kinases

Current Opinion in Cell Biology, 1993
Our current understanding of the eukaryotic cell cycle attributes a key regulatory role to cyclin-dependent protein kinases. It is important, therefore, to identify the physiological substrates of these kinases, and to understand how the phosphorylation of such proteins promotes cell cycle progression.
openaire   +3 more sources

Smad3 phosphorylation by cyclin-dependent kinases

Cytokine & Growth Factor Reviews, 2006
Smad3, a key mediator for TGF-beta antiproliferative responses, is phosphorylated by both CDK4 and CDK2 in vivo and in vitro. Except for the Rb family members, Smad3 is the only CDK4 substrate demonstrated so far. CDK phosphorylation of Smad3 inhibits its transcriptional activity and antiproliferative function.
openaire   +3 more sources

The dynamics of cyclin dependent kinase structure

Current Opinion in Cell Biology, 1996
In the past year, several new crystal structures have provided exciting insights into the conformational changes underlying the regulation of cyclin-dependent kinases. We now understand the structural basis of many of the mechanisms by which cyclin-dependent kinases are regulated, including activation by cyclin binding and phosphorylation, inhibition ...
openaire   +3 more sources

Cloning of p27 Kip1 , a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals

Cell, 1994
K. Polyak, Mong-Hong Lee, H. Erdjument-Bromage, A. Koff, James M. Roberts, P. Tempst, J. Massagué   +6 more
semanticscholar   +1 more source

Measuring Cyclin-Dependent Kinase Activity

2004
The activity of cyclin-dependent kinases (CDKs) lies at the heart of cell cycle and checkpoint control. These complexes have been called the "cell cycle engine," as it is their enzymatic activity that pushes the cells through the cell-division cycle.
openaire   +3 more sources

Cyclin-dependent protein serine/threonine kinase inhibitors as anticancer drugs.

Pharmacological Research, 2019
R. Roskoski
semanticscholar   +1 more source