Results 191 to 200 of about 543,132 (243)
A Review of Melanoma Subtypes: Genetic and Treatment Considerations
Journal of Surgical Oncology, Volume 131, Issue 3, Page 356-364, March 2025.ABSTRACT Melanoma affects over one million people in the United States. This review explores genetic mutations and markers of all seven subtypes. Current treatment options and prognosis of each subtype are also discussed. For lentigo maligna, spitzoid, and nodular subtypes, BRAF was the most common mutation reported. For superficial spreading, TP53 was
Christina Druskovich +4 more
wiley +1 more source
Hormone Receptor Positive Breast Cancer in Young Women: A Review
Journal of Surgical Oncology, Volume 131, Issue 4, Page 580-586, March 15, 2025.ABSTRACT The global incidence of hormone‐positive breast cancer (HR+ BC) in young women is rising, though the underlying reasons remain unclear. HR+ disease in younger women appears to represent a distinct clinical entity compared to that in older women, exhibiting distinct clinicopathological characteristics, outcomes and responses to treatment ...
Nicola McShane +4 more
wiley +1 more source
Protein glycosylation in lung cancer from a mass spectrometry perspective
Mass Spectrometry Reviews, EarlyView.Abstract Lung cancer is a severe disease for which better diagnostic and therapeutic approaches are urgently needed. Increasing evidence implies that aberrant protein glycosylation plays a crucial role in the pathogenesis and progression of lung cancer.
Mirjam Balbisi +2 more
wiley +1 more source
Four‐gene Prognostic Signature and Risk of Brain Metastasis of Lung Adenocarcinoma
Molecular Carcinogenesis, EarlyView.ABSTRACT Brain metastasis has a high incidence and poor prognosis in lung adenocarcinoma (LUAD). We sought to identify genes associated with LUAD brain metastasis and with the prognosis of patients with LUAD. Differential gene expression analysis was performed on LUAD patients with and without distant metastasis from the Cancer Genome Atlas (TCGA ...
Zheng Gong +11 more
wiley +1 more source
The Antiviral Activity of Polyphenols
Molecular Nutrition &Food Research, EarlyView.Polyphenols demonstrate remarkable antiviral properties by effectively disrupting multiple biochemical processes essential for viral replication. ABSTRACT Polyphenols are secondary metabolites produced by a large variety of plants. These compounds that comprise the class of phenolic acids, stilbenes, lignans, coumarins, flavonoids, and tannins have a ...
Markus Burkard +5 more
wiley +1 more source
Effect of Natural Polyphenols on Breast Cancer Chemoprevention and Treatment
Molecular Nutrition &Food Research, EarlyView.Effect of Natural Polyphenols on Breast Cancer proliferation and progression. ABSTRACT Breast cancer is the most common type of malignancy among women worldwide. Significant achievements have been made in diagnostic tools and cancer treatments in the past decade; however, the complexity and heterogeneity of certain breast cancer subtypes often lead to ...
Marzia Sichetti +4 more
wiley +1 more source
ChemistryOpen, EarlyView.Tau protein aggregation and fibrillation have been examined in relationship to three metal ions in this study. The research was conducted to see the effects of Zn2+, Cu2+ and Fe3+ ions at different concentrations on tau′s conformation, cytotoxicity in SH‐SY5Y cells, and free thiol levels.
Mahzad Irandoust +6 more
wiley +1 more source
BMP signalling in colorectal cancer: losing the yin to WNTs yang
The Journal of Pathology, EarlyView.Abstract Colorectal cancer (CRC) is the third most common form of cancer globally, and arises from the hyperproliferation of epithelial cells in the intestine. The architecture and maintenance of these cells is governed by two major signalling pathways working in a counter‐gradient: the stem cell WNT signalling pathway, and the prodifferentiation bone ...
Eloise Clarkson, Annabelle Lewis
wiley +1 more source
Cyclin-Dependent Kinase Inhibits Reinitiation of a Normal S-Phase Program during G2 in Fission Yeast
, 2009 Lee Kiang +4 more
openalex +1 more source
Pediatric Investigation, EarlyView.Retinoma, a benign tumor caused by biallelic retinoblastoma gene (RB1) inactivation, offers key insights into retinoblastoma development and oncogenesis. This review explores its molecular genetics, clinical features, diagnosis, management, and potential implications for advancing the prevention and treatment of retinoblastoma.
Panagiotis N. Toumasis +3 more
wiley +1 more source