Phosphorylation at the Helm: Kinase‐Mediated Regulation of Primary Cilia Assembly and Disassembly
Cytoskeleton, EarlyView.ABSTRACT The primary cilium serves as an antenna of most vertebrate cells and is important for conveying cues from several signaling pathways into appropriate cellular responses during development and homeostasis. Cilia assembly and disassembly processes are thought to be strictly controlled; however, the precise nature of molecular events underlying ...
Andrea Lacigová, Lukáš Čajánek
wiley +1 more source
Cyclin-dependent Kinase 2 Negatively Regulates Human Pregnane X Receptor-mediated CYP3A4 Gene Expression in HepG2 Liver Carcinoma Cells [PDF]
, 2008 Wenwei Lin +5 more
openalex +1 more source
Development of Novel Anticancer Pyrazolopyrimidinones Targeting Glioblastoma
ChemMedChem, Accepted Article.Glioblastoma (GBM) is the most common and aggressive malignant grade IV brain tumour and is one of the most difficult types of brain cancer to treat with a high incidence of resistance to traditionally used chemotherapeutics. Pyrazolopyrimidinones are fused nitrogen‐containing heterocyclic systems which are a scaffold in several bioactive drugs and ...
Kate Byrne +5 more
wiley +1 more source
Inhibition of Cyclin-dependent Kinase 2 Signaling Prevents Liver Ischemia and Reperfusion Injury. [PDF]
Transplantation, 2019 Xu J +7 more
europepmc +1 more source
Cyclin-Dependent Kinase 5 Supports Neuronal Survival through Phosphorylation of Bcl-2 [PDF]
, 2008 Zelda H. Cheung, Ke Gong, Nancy Y. Ip
openalex +1 more source
Bioinformatics analysis of immune‐programmed cell death‐related genes in nasopharyngeal carcinoma
Eye &ENT Research, EarlyView.Abstract Background Nasopharyngeal carcinoma (NPC) is a prevalent malignant tumor of the head and neck, characterized by a complex pathogenesis. Most newly diagnosed NPC patients are locally advanced, and 20%–30% of advanced NPC patients have poor immunotherapy results.
Hongqiang Chen +3 more
wiley +1 more source
DMAPO/Boc2O‐Mediated One‐Pot Direct N‐Acylation of Sulfoximines with Carboxylic Acids
European Journal of Organic Chemistry, Accepted Article.This report describes a general and simple method for the one‐pot direct N‐acylation of sulfoximines with carboxylic acids using our previously developed 4‐(N,N‐dimethylamino)pyridine N‐oxide (DMAPO)/di‐tert‐butyl dicarbonate (Boc2O) system. The method can be performed under mild low‐temperature reaction conditions and has a wide substrate scope.
Atsushi Umehara +2 more
wiley +1 more source
Cyclin E1 and cyclin-dependent kinase 2 are critical for initiation, but not for progression of hepatocellular carcinoma. [PDF]
Proc Natl Acad Sci U S A, 2018 Sonntag R +17 more
europepmc +1 more source
Direct and Indirect Roles of Cyclin-dependent Kinase 5 as an Upstream Regulator in the c-Jun NH2-Terminal Kinase Cascade: Relevance to Neurotoxic Insults in Alzheimer's Disease [PDF]
, 2009 Kai-Hui Sun +3 more
openalex +1 more source
Critical Evaluation of Methods for the Identification of Aneugens
Environmental and Molecular Mutagenesis, EarlyView.ABSTRACT The genotoxic potential of chemicals must be evaluated in regulatory safety assessment settings, including but not limited to, the development of new pharmaceuticals, industrial chemicals, food and cosmetic ingredients, and agrochemicals. Initial assessment of the chromosome‐damaging potential of chemicals is often conducted in mammalian cells
Xiaowen Sun +8 more
wiley +1 more source