Results 171 to 180 of about 33,889 (223)

Preliminary Effects of Benralizumab in an AML Cell Model with Promyelocytic Features Expressing IL-5R: An Exploratory Proof-of-Concept Study. [PDF]

Biomedicines
Piazzetta GL, Di Agostino S, Lobello N, Aloisio A, Di Vito A, Bria J, Filardo A, Coscarella I, Preianò M, Pelaia C, Lombardo N, Chiarella E.   +11 more
europepmc   +1 more source

Metformin-Mediated Glycaemic Regulation as a Potential Strategy for Breast Cancer Prevention. [PDF]

Cancer Med
Jinadasa AGRG, Wageesha NDA, Samarakoon SR, Ekanayake S, Akalanka HMK.   +4 more
europepmc   +1 more source

Regulation of the cyclin-dependent kinase inhibitor p27 by degradation and phosphorylation [PDF]

Leukemia, 1997
The cell cycle has been the object of extensive studies for the past years. A complex network of molecular interactions has been identified. In particular, a class of cell cycle inhibitory proteins has been cloned and characterized but details of the molecular mechanism of their action have yet to be resolved.
A, Alessandrini, D S, Chiaur, M, Pagano
exaly   +3 more sources

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Molecular characterization of the cyclin-dependent kinase inhibitor p27 promoter

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1997
p27Kip1 is a member of the family of cyclin-dependent kinase inhibitors (CKIs), which play critical roles in the regulation of cell cycle. To study the transcriptional regulation that controls the expression of p27, we have isolated the p27 promoter, defined its transcription initiation site, and performed various analyses for sequences upstream to 3 ...
Zhang, Y., Lin, S. C.
openaire   +2 more sources

Expression of the cyclin-dependent kinase inhibitor p27 in keratoacanthoma

Journal of the American Academy of Dermatology, 2000
Keratoacanthomas are characterized by initial rapid enlargement followed by clinical regression. A series of cyclin and cyclin-dependent kinase complexes regulate cell cycle progression. p27(kip) inhibits a variety of cyclin-cyclin-dependent kinase complexes in vitro and may act to hold eukaryotic cells in a quiescent state (G0).We examined expanding ...
W, Hu, T, Cook, C W, Oh, N S, Penneys
openaire   +2 more sources

Enhanced Growth of Mice Lacking the Cyclin-Dependent Kinase Inhibitor Function of p27 [PDF]

Cell, 1996
Hiroaki Kiyokawa, Rhonda D Kineman, Adrian Clive Hayday   +2 more
exaly   +2 more sources

Cycline‐Dependent Kinase Inhibitor, p27 (KIP1), Is Associated With Cholesteatoma

The Laryngoscope, 2001
AbstractObjective Cyclin‐dependent kinases (CDKis) can arrest the cell cycle, which in turn inhibits the cell proliferation. P27 (KIP1) is a CDKi and acts as a tumor suppressor gene. In this study, we aimed to investigate the role of p27 CDKi in cholesteatoma, a disease characterized by the presence of hyperproliferative squamous epithelium.Study ...
Y A, Bayazít, M, Karakök, R, Uçak, M, Kanlíkama   +3 more
openaire   +2 more sources

Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27.

The EMBO journal, 1997
The p27(Kip1) protein associates with G1-specific cyclin-CDK complexes and inhibits their catalytic activity. p27(Kip1) is regulated at various levels, including translation, degradation by the ubiquitin/proteasome pathway and non-covalent sequestration. Here, we describe point mutants of p27 deficient in their interaction with either cyclins (p27(c-)),
J, Vlach, S, Hennecke, B, Amati
openaire   +2 more sources

Modulation of astrocyte proliferation by cyclin‐dependent kinase inhibitor p27^Kip1

Glia, 2001
AbstractWe previously demonstrated that type 1 astrocytes exhibited homotypic cell contact‐dependent inhibition of proliferation with increased expression of cyclin‐dependent kinase inhibitor p27Kip1. Here, we investigated the functional role of p27 in contact‐dependent inhibition of astrocytes and reactive gliosis in vitro and in vivo.
Ken, Koguchi, Yuji, Nakatsuji, Kei-Ichi, Nakayama, Saburo, Sakoda   +3 more
openaire   +2 more sources

Cyclin-dependant kinase inhibitors CIP1 (p21) and KIP1 (p27) in ovarian cancer

Journal of Cancer Research and Clinical Oncology, 2005
Deregulation of the cell cycle is one of the important prerequisites for cancer development. p21 and p27 are both universal inhibitors of cyclin-dependent kinases and can therefore influence cell cycle or tumor progression. The aim of this study was to determine the influence of p21 and p27 expression on survival and chemotherapy response.165 patients ...
Annette, Schmider-Ross, Olaf, Pirsig, Elisabeth, Gottschalk, Carsten, Denkert, Werner, Lichtenegger, Angela, Reles   +5 more
openaire   +2 more sources