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Chemical inhibitors of cyclin-dependent kinases
Trends in Cell Biology, 1995The eukaryotic cell division cycle is regulated by a family of protein kinases, the cyclin-dependent kinases (cdk's), constituted of at least two subunits, a catalytic subunit (cdk1-7) associated with a regulatory subunit (cyclin A-H). Transient activation of cdk's is responsible for transition through the different phases of the cell cycle.
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Pharmacological inhibitors of cyclin-dependent kinases
Trends in Pharmacological Sciences, 2002Cyclin-dependent kinases (CDKs) regulate the cell division cycle, apoptosis, transcription and differentiation in addition to functions in the nervous system. Deregulation of CDKs in various diseases has stimulated an intensive search for selective pharmacological inhibitors of these kinases.
Marie Knockaert +2 more
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Cyclins, cyclin‐dependent kinases and differentiation
BioEssays, 1997AbstractCyclin‐dependent kinases and their regulatory subunits, the cyclins, are known to regulate progression through the cell cycle. Yet these same proteins are often expressed in non‐cycling, differentiated cells. This review surveys the available information about cyclins and cyclin‐dependent kinases in differentiated cells and explores the ...
Chun Y. Gao, Peggy S. Zelenka
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Functional Evolution of Cyclin-Dependent Kinases
Molecular Biotechnology, 2009Cyclin-dependent kinases (CDKs) are serine/threonine protein kinases with a well established role in the regulation of the eukaryotic cell cycle. Recent studies with animal cells have implicated CDK activity in additional diverse cellular processes, including transcription, translation and mRNA processing.
John H. Doonan, Georgios Kitsios
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Cyclin-dependent kinases in brain development and disease.
Annual Review of Cell and Developmental Biology, 2011Cyclin-dependent kinase 5 (Cdk5) is a multifaceted serine/threonine kinase protein with important roles in the nervous system. Two related proteins, p35 and p39, activate Cdk5 upon direct binding. Over the past decade, Cdk5 activity has been demonstrated
Susan C. Su, L. Tsai
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p27KIP1, an inhibitor of cyclin-dependent kinases
1995The identification of a family of proteins that stoichiometrically regulate the activation of the G1 cyclin-dependent kinases has added to our understanding of the process of commitment to the mitotic cycle. The properties of p27 as a CDK binding protein, the ability of environmental signals to regulate the expression of p27, and the observation that ...
Kornelia Polyak, Andrew Koff
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Journal of Medicinal Chemistry, 2006
Cyclin dependent kinases are a key family of kinases involved in cell cycle regulation and are an attractive target for cancer chemotherapy. The roles of four residues of the cyclin-dependent kinase active site in inhibitor selectivity were investigated by producing cyclin-dependent kinase 2 mutants bearing equivalent cyclin-dependent kinase 4 residues,
Pratt DJ +5 more
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Cyclin dependent kinases are a key family of kinases involved in cell cycle regulation and are an attractive target for cancer chemotherapy. The roles of four residues of the cyclin-dependent kinase active site in inhibitor selectivity were investigated by producing cyclin-dependent kinase 2 mutants bearing equivalent cyclin-dependent kinase 4 residues,
Pratt DJ +5 more
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Cyclin-dependent kinases as targets for cancer therapy
Update on Cancer Therapeutics, 2003Cell cycle perturbations are commonly observed in human malignancies. Exploiting this finding is the rationale for the development of CDK inhibitors as anti-tumor agents. Single-agent evaluation of several CDKIs has demonstrated limited clinical activity.
Gary K. Schwartz, Manish A. Shah
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The dynamics of cyclin dependent kinase structure
Current Opinion in Cell Biology, 1996In the past year, several new crystal structures have provided exciting insights into the conformational changes underlying the regulation of cyclin-dependent kinases. We now understand the structural basis of many of the mechanisms by which cyclin-dependent kinases are regulated, including activation by cyclin binding and phosphorylation, inhibition ...
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Targets of cyclin-dependent protein kinases
Current Opinion in Cell Biology, 1993Our current understanding of the eukaryotic cell cycle attributes a key regulatory role to cyclin-dependent protein kinases. It is important, therefore, to identify the physiological substrates of these kinases, and to understand how the phosphorylation of such proteins promotes cell cycle progression.
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