Results 351 to 360 of about 382,305 (392)

Smad3 phosphorylation by cyclin-dependent kinases

Cytokine & Growth Factor Reviews, 2006
Smad3, a key mediator for TGF-beta antiproliferative responses, is phosphorylated by both CDK4 and CDK2 in vivo and in vitro. Except for the Rb family members, Smad3 is the only CDK4 substrate demonstrated so far. CDK phosphorylation of Smad3 inhibits its transcriptional activity and antiproliferative function.
openaire   +3 more sources

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

Cell, 1993
J. Harper, G. Adami, N. Wei, K. Keyomarsi, S. Elledge   +4 more
semanticscholar   +1 more source

Measuring Cyclin-Dependent Kinase Activity

2004
The activity of cyclin-dependent kinases (CDKs) lies at the heart of cell cycle and checkpoint control. These complexes have been called the "cell cycle engine," as it is their enzymatic activity that pushes the cells through the cell-division cycle.
openaire   +3 more sources

Beyond PI3Ks: targeting phosphoinositide kinases in disease

Nature Reviews Drug Discovery, 2023
Joanna Triscott, John E Burke, Brooke M Emerling   +2 more
exaly  

Assays for Cyclin-Dependent Kinase Inhibitors [PDF]

, 2003
Tyler Lahusen, Adrian M. Senderowicz
openaire   +2 more sources

Cyclins, Cyclin-Dependent Kinases, and Cyclin-Dependent Kinase Inhibitors: Detection Methods and Activity Measurements

2004
The cyclin/cyclin-dependent kinase (Cdk) complexes and the Cdk inhibitors (CDKI) are crucial regulators of cell cycle progression in all eukaryotic cells. Using rat cardiac myocytes as a model system, this chapter provides a detailed account of methods that can be employed to measure both cyclin/Cdk activity in cells and the extent of CDKI inhibitory ...
openaire   +3 more sources

The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA

Nature, 1994
S. Waga, G. Hannon, D. Beach, B. Stillman   +3 more
semanticscholar   +1 more source

Cyclins and Cyclin-Dependent Kinases

, 2016
Nathan H. Lents, J. Baldassare
semanticscholar   +1 more source

Cell cycle kinases as therapeutic targets for cancer

Nature Reviews Drug Discovery, 2009
Antonio Giordano
exaly  

Cyclin-Dependent Kinases

2008
openaire   +1 more source