Results 371 to 380 of about 483,027 (406)
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European Journal of Biochemistry, 1997
Cyclin-dependent kinases (cdk) play an essential role in the intracellular control of the cell division cycle (cdc). These kinases and their regulators are frequently deregulated in human tumours.
L. Meijer +8 more
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Cyclin-dependent kinases (cdk) play an essential role in the intracellular control of the cell division cycle (cdc). These kinases and their regulators are frequently deregulated in human tumours.
L. Meijer +8 more
semanticscholar +1 more source
Breast Cancer Research and Treatment, 1998
Cyclins are regulatory subunits for cyclin dependent kinases in the coordination of the cell cycle. Cyclins can also serve non-cell cycle functions, such as the transactivation of estrogen receptor by cyclin D. Evidence for the participation of the G1 cyclins D and E in breast cancer is summarized, including transgenic and knockout mice, transfections,
Qun Zhou, Patricia S. Steeg
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Cyclins are regulatory subunits for cyclin dependent kinases in the coordination of the cell cycle. Cyclins can also serve non-cell cycle functions, such as the transactivation of estrogen receptor by cyclin D. Evidence for the participation of the G1 cyclins D and E in breast cancer is summarized, including transgenic and knockout mice, transfections,
Qun Zhou, Patricia S. Steeg
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Cyclin A and cyclin B1 overexpression in differentiated thyroid carcinoma
Medical Oncology, 2011Approximately 30% of patients with thyroid nodules have indeterminate or suspicious fine-needle aspiration (FNA) biopsy results. These patients usually undergo thyroidectomy because of cancer risk. Our aim was to determine diagnostic value of cyclin A and cyclin B1 immunohistochemistry added to routine cytology and their expression on histological ...
Asli Nar +3 more
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Cyclins and Cyclin-Dependent Kinases: Theme and Variations
1995Publisher Summary This chapter introduces cyclins and their partner—cyclin dependent kinases (CDKs)—and the ways in which CDK complexes can be regulated. Cyclins are intimately concerned with regulating and coordinating deoxyribonucleic acid (DNA) replication and cell division.
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Cyclin specificity in the phosphorylation of cyclin-dependent kinase substrates
Nature, 2005Cell-cycle events are controlled by cyclin-dependent kinases (CDKs), whose periodic activation is driven by cyclins. Different cyclins promote distinct cell-cycle events, but the molecular basis for these differences remains unclear. Here we compare the specificity of two budding yeast cyclins, the S-phase cyclin Clb5 and the M-phase cyclin Clb2, in ...
Mart Loog, David O. Morgan
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Mitotic cyclins and cyclin-dependent kinases in melanocytic lesions
Human Pathology, 1998Recent evidence has implicated cyclins and cyclin-dependent kinases in the evolution and progression of various malignancies. We studied the immunohistochemical expression of cyclin A, cyclin B, and cyclin-dependent kinase p34cdc2 in a broad spectrum of benign and malignant melanocytic lesions.
Tien-Anh Tran +3 more
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Distinct roles for cyclin-dependent kinases in cell cycle control.
Science, 1993The key cell-cycle regulator Cdc2 belongs to a family of cyclin-dependent kinases in higher eukaryotes. Dominant-negative mutations were used to address the requirement for kinases of this family in progression through the human cell cycle.
S. V. D. Heuvel, E. Harlow
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Cyclin-dependent kinase pathways as targets for cancer treatment.
Journal of Clinical Oncology, 2006Cyclin-dependent kinases (cdks) are critical regulators of cell cycle progression and RNA transcription. A variety of genetic and epigenetic events cause universal overactivity of the cell cycle cdks in human cancer, and their inhibition can lead to both
G. Shapiro
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G2 cyclins are required for the degradation of G1 cyclins in yeast
Nature, 1996Progression of the eukaryotic cell cycle is controlled by cyclin-dependent kinases (CDKs). Cdc28, the budding yeast homologue of Cdc2 (Cdk1), is required for both the G1/S and G2/M transitions of the cell cycle. The functional specificity of the Cdc28 kinase is determined by its association with G1 or G2 cyclins.
Marc Blondel, Carl Mann
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A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4
Nature, 1993M. Serrano, G. Hannon, D. Beach
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