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Mitotic cyclins and cyclin-dependent kinases in melanocytic lesions

Human Pathology, 1998
Recent evidence has implicated cyclins and cyclin-dependent kinases in the evolution and progression of various malignancies. We studied the immunohistochemical expression of cyclin A, cyclin B, and cyclin-dependent kinase p34cdc2 in a broad spectrum of benign and malignant melanocytic lesions.
Tien-Anh Tran +3 more
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G2 cyclins are required for the degradation of G1 cyclins in yeast

Nature, 1996
Progression of the eukaryotic cell cycle is controlled by cyclin-dependent kinases (CDKs). Cdc28, the budding yeast homologue of Cdc2 (Cdk1), is required for both the G1/S and G2/M transitions of the cell cycle. The functional specificity of the Cdc28 kinase is determined by its association with G1 or G2 cyclins.
Marc Blondel, Carl Mann
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Cyclin activation of p34cdc2

Cell, 1990
The gradual accumulation of cyclin in the frog egg induces an abrupt and concerted activation of p34cdc2 that initiates mitosis. Activation is delayed even after the accumulation of cyclin to a critical threshold concentration. We have reproduced these unusual kinetic properties of p34cdc2 activation in vitro using bacterially expressed cyclin proteins
Michael Glotzer +4 more
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Cyclin A is required at two points in the human cell cycle.