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Trends in Plant Science, 2018
Although widely used as a marker for cell proliferation, CYCB1;1 expression is also strongly induced in cells that suffer from DNA damage. Recently, this enigmatic dual expression pattern has been resolved by proving that CYCB1;1 promotes DNA repair. This has consequences for using CYCB1;1 as a cell cycle reporter.
Arp Schnittger, Lieven De Veylder
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Although widely used as a marker for cell proliferation, CYCB1;1 expression is also strongly induced in cells that suffer from DNA damage. Recently, this enigmatic dual expression pattern has been resolved by proving that CYCB1;1 promotes DNA repair. This has consequences for using CYCB1;1 as a cell cycle reporter.
Arp Schnittger, Lieven De Veylder
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Cyclin A and cyclin B1 overexpression in differentiated thyroid carcinoma
Medical Oncology, 2011Approximately 30% of patients with thyroid nodules have indeterminate or suspicious fine-needle aspiration (FNA) biopsy results. These patients usually undergo thyroidectomy because of cancer risk. Our aim was to determine diagnostic value of cyclin A and cyclin B1 immunohistochemistry added to routine cytology and their expression on histological ...
Asli Nar +3 more
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Aberrant expression of cyclin A and cyclin B1 proteins in oral carcinoma
Journal of Oral Pathology & Medicine, 1999Cyclins play an important role in regulating the passage of dividing cells through critical checkpoints in cell cycle. Aberrant exprssion of cylcin proteins has been found in a number of human cancers, including carcinomas of the head and neck, where amplification of the cyclin D1 gene is a common finding. The obective of this study was to examine cell
Beverley Young +3 more
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Cyclins A and B1 in the human cell cycle.
Ciba Foundation symposium, 1992Cyclins are a family of proteins involved in the regulation of the eukaryotic cell cycle. The first cyclins to be isolated were the A- and B-type cyclins and we have been studying their behaviour in human somatic cells. The levels of both cyclin A and B1 are regulated transcriptionally as well as post-translationally; both are rapidly and specifically ...
Tony Hunter, Jonathon Pines
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The prognostic value of Cyclin B1 in pancreatic cancer
Medical Oncology, 2014Pancreatic cancer (PC), a malignancy with very poor prognosis, presents many molecular alterations, including overexpression of Cyclin B1. However, the prognostic value of the protein in PC remains to be elucidated. In the present study, Cyclin B1 expression was detected immunohistochemically in specimens from 241 patients with PC and was correlated ...
Wen-Ming Wu +8 more
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Unmasking the S-Phase-Promoting Potential of Cyclin B1
Science, 2003In higher eukaryotes, the S phase and M phase of the cell cycle are triggered by different cyclin-dependent kinases (CDKs). For example, in frog egg extracts, Cdk1–cyclin B catalyzes entry into mitosis but cannot trigger DNA replication. Two hypotheses can explain this observation: Either Cdk1–cyclin B fails to recognize the key substrates of its S ...
Tim Hunt, Jonathan D. Moore, Jane Kirk
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Prognostic significance of cyclin A and B1 in pediatric embryonal tumors [PDF]
Journal of Neuro-Oncology, 2010 Embryonal tumors constitute the most common malignant brain tumor group in children. Although patient prognosis has been substantially improved over recent decades, identification of prognostic markers would be of obvious significance. In the present study we evaluated the prognostic significance of cyclin A and B1 in correlation with Ki-67 index in ...
Maria Moschovi +7 more
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Overexpression of cyclin B1 in human colorectal cancers
Journal of Cancer Research and Clinical Oncology, 1997The expression of the human cyclin B1 gene was investigated with Western blot analysis in human colorectal carcinomas and in adjacent non-neoplastic colorectal mucosas. Out of 41 cancers, 36 (88% of patients) showed much higher expression of cyclin B1 than did the non-neoplastic mucosa.
Takuji Tanaka +4 more
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The significance of cyclin B1 expression in colorectal cancers
The Chinese-German Journal of Clinical Oncology, 2006To study the relationship between the expression of human cyclin B1 in colorectal carcinomas and the pathological characters. The Expression of cyclin B1 in 66 cases of colorectal carcinomas were detected by flow cytometry and immunohistochemistry.
Xiaojun He +6 more
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Temporal and spatial control of cyclin B1 destruction in metaphase
Nature Cell Biology, 1999The proteolysis of key regulatory proteins is thought to control progress through mitosis. Here we analyse cyclin B1 degradation in real time and find that it begins as soon as the last chromosome aligns on the metaphase plate, just after the spindle-assembly checkpoint is inactivated. At this point, cyclin B1 staining disappears from the spindle poles
Jonathon Pines, Paul Clute
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