Results 261 to 269 of about 63,908 (269)
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CDK5–cyclin B1 regulates mitotic fidelity
NatureCDK1 has been known to be the sole cyclin-dependent kinase (CDK) partner of cyclin B1 to drive mitotic progression1. Here we demonstrate that CDK5 is active during mitosis and is necessary for maintaining mitotic fidelity. CDK5 is an atypical CDK owing to its high expression in post-mitotic neurons and activation by non-cyclin proteins p35 and p392 ...
Xiao-Feng Zheng +15 more
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Cyclin B1 is an efficacy-predicting biomarker for Chk1 inhibitors
Biomarkers, 2008Chk1 is the major mediator of cell-cycle checkpoints in response to various forms of genotoxic stress. Although it was previously speculated that checkpoint abrogation due to Chk1 inhibition may potentiate the efficacy of DNA-damaging agents through induction of mitotic catastrophe, there has not been direct evidence proving this process. Here, through
Wen-Zhen Gu +8 more
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Aurora-A interacts with Cyclin B1 and enhances its stability
Cancer Letters, 2009The mitotic regulator Aurora-A is an oncogenic protein that is over-expressed in many types of human tumors. However, the underlying mechanism through which Aurora-A promotes tumorigenesis remains unclear. Here, we show that overexpression of Aurora-A causes an elevation of Cyclin B1 expression.
Fei-Yue Fan +5 more
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Expression and prognostic significance of cyclin B1 and cyclin A in non‐small cell lung cancer
Histopathology, 2009Aims: Aberrant expression of cell cycle regulators has been implicated in the pathogenesis of many neoplasms, including non‐small cell lung cancer (NSCLC). The aim was to examine the expression and prognostic value of cyclin B1 and cyclin A, key regulators of the G2/M checkpoint of the cell cycle, in NSCLC and bronchial precursor lesions.Methods and ...
Maija R.J. Kohonen-Corish +6 more
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Cyclin B1 expression in meiotically competent and incompetent goat oocytes
Molecular Reproduction and Development, 1997To start determining the nature of meiotic incompetence in goat oocytes, we have examined the expression of one of the potential pre-MPF subunits: the cyclin B1. We have been isolating a small DNA probe encoding the goat cyclin B1 box to analyze the expression of the cyclin B1 gene in competent and incompetent goat oocytes.
Hue, Isabelle +5 more
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Nature, 1999
In mammalian somatic-cell cycles, progression through the G1-phase restriction point and initiation of DNA replication are controlled by the ability of the retinoblastoma tumour-suppressor protein (pRb) family to regulate the E2F/DP transcription factors.
Claes Lindeneg +7 more
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In mammalian somatic-cell cycles, progression through the G1-phase restriction point and initiation of DNA replication are controlled by the ability of the retinoblastoma tumour-suppressor protein (pRb) family to regulate the E2F/DP transcription factors.
Claes Lindeneg +7 more
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The immunohistochemical outline of p27kip1, cyclin B1 and cyclin D3 in pleomorphic adenomas.
Minerva stomatologica, 2006Pleomorphic adenomas of salivary glands are benign lesions which may sometimes relapse even after complete surgical removal. This risk has led to the search for methods to provide predictive data on the biological behaviour of such neoplasia. The authors intend to evaluate the degree of cellular aggression of these tumours by finding prognostic data ...
RULLO, Rosario +3 more
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ABERRANT CYCLIN A AND CYCLIN B1 PROTEIN EXPRESSION IN ASTROCYTOMA
Journal of Neuropathology and Experimental Neurology, 1998L. C. Ang +4 more
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P.210 Immunohistochemical expression of cyclin D1 and cyclin B1 in oral leukoplakia
Journal of Cranio-Maxillofacial Surgery, 2006Shosuke Morita +3 more
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