Results 331 to 340 of about 592,070 (354)

Dengue virus modulates critical cell cycle regulatory proteins in human megakaryocyte cells. [PDF]

Sci Rep
Basak S, Dutta S, Khanal S, Neelakanta G, Sultana H.   +4 more
europepmc   +1 more source

Rare Case of Mantle Cell Lymphoma With Multiple Rectal Lesions

United European Gastroenterology Journal, EarlyView.
Lumir Kunovsky, Eliska Tvrdikova, Jozef Michalka, Jan Trna   +3 more
wiley   +1 more source

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CRL4AMBRA1 is a master regulator of D-type cyclins

Nature, 2021
D-type cyclins are central regulators of the cell division cycle and are among the most frequently deregulated therapeutic targets in human cancer1, but the mechanisms that regulate their turnover are still being debated2,3. Here, by combining biochemical and genetics studies in somatic cells, we identify CRL4AMBRA1 (also known as CRL4DCAF3) as the ...
Valentina Cianfanelli, Yeon-Tae Jeong, David Fenyö, Francesca Nazio, Andrew A. Wang, Nan Zhou, Sorasicha Nithikasem, Daniele Simoneschi, Arnaldo A. Arbini, Emiliano Maiani, Alfie O’sullivan, Yik Siu, Drew R. Jones, Luca Busino, Francesco Boccalatte, Gergely Róna, Francesco Cecconi, Francesco Cecconi, Shaowen Jiang, Sarah Keegan, Giacomo Milletti, Giacomo Milletti, Michele Pagano   +22 more
openaire   +5 more sources

Cyclin D and oncogenesis

Current Opinion in Genetics & Development, 1993
The D-type cyclins are among the candidate 'G1 cyclins' in higher eukaryotes that may regulate G1-S-phase progression. The human cyclin D1 gene, also known as PRAD1 (and previously as D11S287), is a putative proto-oncogene strongly implicated in several types of human tumors, including parathyroid adenomas, B-cell neoplasms (as the 'BCL-1 oncogene ...
Andrew Arnold, Toru Motokura
openaire   +3 more sources

Human D-type cyclin

Cell, 1991
A cDNA library prepared from a human glioblastoma cell line has been introduced into a budding yeast strain that lacks CLN1 and CLN2 and is conditionally deficient for CLN3 function. We rescued a gene that we call cyclin D1. It is related to A-, B-, and CLN-type cyclins, but appears to define a new subclass within the cyclin gene family.
Yue Xiong, Bruce Futcher, T Connolly, David Beach   +3 more
openaire   +3 more sources

Uncovering the degrader of D-type cyclins

Science, 2022
AMBRA1 is identified as the long-sought, major controller of D-type ...
openaire   +2 more sources

Cyclin D as a therapeutic target in cancer

Nature Reviews Cancer, 2011
Cyclin D1, and to a lesser extent the other D-type cyclins, is frequently deregulated in cancer and is a biomarker of cancer phenotype and disease progression. The ability of these cyclins to activate the cyclin-dependent kinases (CDKs) CDK4 and CDK6 is the most extensively documented mechanism for their oncogenic actions and provides an attractive ...
Jane Barraclough, Elizabeth A. Musgrove, Andrew Stone, C. Elizabeth Caldon, Robert L. Sutherland, Robert L. Sutherland   +5 more
openaire   +3 more sources

D-type cyclins

Trends in Biochemical Sciences, 1995
D-type cyclins couple extracellular signals to the biochemical machinery that governs progression through G1 phase of the mammalian cell division cycle. Induced by growth factor stimulation, D-type cyclins assemble with cyclin-dependent kinases CDK4 and CDK6 to form holoenzymes that facilitate exit from G1 by phosphorylating key substrates, including ...
openaire   +3 more sources

The path to destruction for D-type cyclin proteins

Nature, 2021
The molecular mechanism governing the destruction of key cell-cycle proteins, D-type cyclins, has been elucidated. This mechanism might underlie the lack of response of some human tumours to an inhibitor treatment. Mechanism discovered for the degradation of key cell-cycle regulators.
Piotr Sicinski, Charupong Saengboonmee
openaire   +2 more sources

The D-type cyclins and their role in tumorigenesis

Journal of Cell Science, 1994
SUMMARY The D-type cyclins are expressed during the progression from G0/G1 to S phase in the mammalian cell cycle. There is considerable evidence that they contribute to the development of specific cancers, both in humans and in mouse models.
openaire   +3 more sources