Results 341 to 350 of about 592,070 (354)

Cyclin D expression in chronic lymphocytic leukemia

Leukemia & Lymphoma, 2005
Although the majority of circulating leukemic cells in chronic lymphocytic leukemia (CLL) are in G0/early G1, recent studies have shown that these cells have undergone multiple cell divisions. In this study, we have determined whether there are abnormalities in cell cycle control in CLL by examining the three cyclin D isoforms in 43 patients and ...
Elizabeth S. Henson, James B. Johnston, James T. Paul, Mary Cheang, J. Frederic Mushinski, Spencer B. Gibson, Sabine Mai   +6 more
openaire   +3 more sources

Cyclin D-CDK4/6 functions in cancer

2020
The mammalian cell cycle is driven by a complex of cyclins and their associated cyclin-dependent kinases (CDKs). Abnormal dysregulation of cyclin-CDK is a hallmark of cancer. D-type cyclins and their associated CDKs (CDK4 and CDK6) are key components of cell cycle machinery in driving G1 to S phase transition via phosphorylating and inactivating the ...
Gustavo Leone, Xueliang Gao, Haizhen Wang   +2 more
openaire   +3 more sources

Hedgehog regulates cell growth and proliferation by inducing Cyclin D and Cyclin E

Nature, 2002
Although mutations that activate the Hedgehog (Hh) signalling pathway have been linked to several types of cancer, the molecular and cellular basis of Hh's ability to induce tumour formation is not well understood. We identified a mutation in patched (ptc), an inhibitor of Hh signalling, in a genetic screen for regulators of the Retinoblastoma (Rb ...
Molly Duman-Scheel, Shiljie Xin, Li Weng, Wei Du   +3 more
openaire   +3 more sources

Cyclin D control of growth rate in plants

Nature, 2000
The mechanisms by which plants modulate their growth rate in response to environmental and developmental conditions are unknown, but are presumed to involve specialized regions called meristems where cell division is concentrated. The possible role of cell division in influencing meristem activity and overall plant growth rate is controversial, with a ...
James A. H. Murray, B. G. W. den Boer, C. E. Cockcroft, J. M. S. Healy, J. M. S. Healy   +4 more
openaire   +3 more sources

The effect of hydrogen peroxide on the cyclin D expression in fiborblasts

Cellular and Molecular Life Sciences, 2001
Activation of mitogen-activated protein (MAP) kinase is essential for cyclin D1 expression and provides a link between mitogenic signalling and cell cycle progression. Hydrogen peroxide (H2O2) activates MAP kinase; however, it is not known whether this leads to cyclin D expression.
Johannes Boonstra, Arie J. Verkleij, C. Martínez Munõz, Jan A. Post, C. T. Verrips   +4 more
openaire   +4 more sources

The D-Type Cyclins: A Historical Perspective

2017
D-type cyclins integrate mitogen-dependent signals to enforce progression through the first gap phase (G1) of the cell division cycle. In simplest terms, three mammalian D-type cyclins (D1, D2, and D3), induced in a cell lineage-specific fashion in response to extracellular signals, interact with two cyclin-dependent kinases (CDK4 and CDK6) to form ...
Peter Sicinski, Charles J. Sherr
openaire   +2 more sources

No Blood Cells Without Cyclin D

Science Signaling, 2014
Conditional knockout in adult mice of D-type cyclins results in complete loss of hematopoietic cells.
openaire   +2 more sources

D-Type Cyclins and Gene Transcription

2017
D-type cyclins contribute the regulatory subunits to the holoenzymes that phosphorylate distinct substrates and regulate diverse biological processes, including cellular proliferation and differentiation. A growing body of evidence has demonstrated that the D-type cyclins are located in distinct subcellular pools with distinct functions.
Zhiping Li, Adam Ertel, Mathew C. Casimiro, Gabriele Di Sante, Peter Tompa, Peter Tompa, Richard G. Pestell   +6 more
openaire   +2 more sources

Regulation of the embryonic cell proliferation by Drosophila cyclin D and cyclin E complexes.

Novartis Foundation symposium, 2001
Cell proliferation during Drosophila development occurs in a well known spatial and temporal pattern which can readily be studied in vivo. The cells which form the larval epidermis exit from the cell division cycle during embryogenesis after the 16th round of mitosis when they enter for the first time into a G1/0 phase.
K. Sauer, Claas A. Meyer, Henning W. Jacobs, Christian F. Lehner   +3 more
openaire   +2 more sources

Monoclonal Antibodies to Mammalian D-Type G1 Cyclins

Hybridoma, 1994
D-type cyclins are necessary and rate-limiting for G1 progression during the mammalian cell cycle. Cyclins D1, D2, and D3 are encoded by distinct genes and are expressed in proliferating cells in a lineage-specific manner. Monoclonal antibodies (mAbs) generated to bacterially produced recombinant D-type cyclins were able to react with the native ...
David K. Strom, Horng-Mo Lee, Susan J. Vallance, Sheila A. Shurtleff, Jun-ya Kato, Martine F. Roussel, Charles J. Sherr   +6 more
openaire   +3 more sources