Results 301 to 310 of about 152,964 (318)
Nature, 2011 Cyclin D1 is one of the drivers of the cell cycle, and its deregulation may promote the development of tumours. Surprisingly, this protein also mediates the repair of damaged DNA, a mechanism that commonly prevents cancer. See Letter p.230 Cyclin D1 has a crucial role in the cell cycle and is often ...
Jiri Lukas, Jiri Bartek
openaire +1 more source
Some of the next articles are maybe not open access.
Related searches:
Related searches:
Cyclin D1 as a target for chemoprevention
Lung Cancer, 2003Lung cancer is the leading cause of cancer mortality. Chemoprevention is an attractive strategy to combat this major public health problem. Pre-clinical and clinical studies have identified diverse candidate chemopreventive agents that affect cellular proliferation, differentiation, apoptosis and tumor angiogenesis, among other pathways.
Konstantin H. Dragnev +4 more
openaire +3 more sources
Cyclin D1 positive follicular lymphoma [PDF]
Journal of Clinical Pathology, 2009 This report describes an unusual case of cyclin D1 expression by an otherwise typical follicular lymphoma, of low histological grade. BCL2–IGH and CCND1–IGH fusions were identified by interphase fluorescence in situ hybridisation.
B, Olsen +4 more
openaire +2 more sources
Cyclin D1 in mammary carcinoma
The Journal of Pathology, 1997The control of the cell-cycle-associated protein cyclin D1 and its variable behaviour in normal and transformed cells is described and contrasted with its activity in vivo. The role of cyclin D1 as a prognostic and predictive marker is examined in clinical breast cancer.
openaire +3 more sources
Regulation of cyclin D1 gene expression
Biochemical Society Transactions, 2010Cyclin D1 is a key regulator of cell proliferation and its expression is subject to both transcriptional and post-transcriptional regulation. In different cellular contexts, different pathways assume a dominant role in regulating its expression, whereas their disregulation can contribute to overexpression of cyclin D1 in tumorigenesis. Here, we discuss
Ini Isabée Witzel +3 more
openaire +3 more sources
The activities of cyclin D1 that drive tumorigenesis
Trends in Molecular Medicine, 2004The proto-oncogene cyclin D1 has been implicated in the genesis of a large proportion of human tumors from diverse histological origins. It has long been assumed that the action of cyclin D1, as an activator of cdk4 and cdk6 and leading to progression through the G1 phase of the cell cycle, underlies its pathological activity.
Justin Lamb, Mark E. Ewen
openaire +3 more sources
Cyclin D1 in Breast Cancer Pathogenesis
Journal of Clinical Oncology, 2005Taking a perspective on available evidence that emphasizes relevance to human disease, cyclin D1 is solidly established as an oncogene with an important pathogenetic role in breast cancer and other human tumors. However, the precise cellular mechanisms through which aberrant cyclin D1 expression drives human neoplasia are less well established. Indeed,
Alexandros Papanikolaou, Andrew Arnold
openaire +3 more sources
Cyclin D1 as a cellular proto-oncogene
Seminars in Cancer Biology, 1995Deregulated expression of cyclin D1 occurs in several types of human cancer. Since it often results from a specific chromosomal abnormality, this over-expression is likely to be significant in the development of the disease. Cyclin D1 is also implicated in virally induced tumors in mice and transgenic models based on ectopic expression if cyclin D1 ...
Gordon Peters, Stewart Bates
openaire +3 more sources
2016
Two proto-oncogenes from the Cyclin protein family that are involved in the regulation of the cell cycle are described in this chapter. Cyclin D1 gene or CCND1 is involved in the regulation of the cell cycle and becomes most abundant in the G1 phase in the lead up to DNA replication. The activity of the cyclin D in normal cell physiology contributes to
openaire +2 more sources
Two proto-oncogenes from the Cyclin protein family that are involved in the regulation of the cell cycle are described in this chapter. Cyclin D1 gene or CCND1 is involved in the regulation of the cell cycle and becomes most abundant in the G1 phase in the lead up to DNA replication. The activity of the cyclin D in normal cell physiology contributes to
openaire +2 more sources
Ras regulation of cyclin D1 promoter
2001Publisher Summary This chapter focuses on the Ras regulation of Cyclin D 1 promoter. Cyclin D l, the regulatory subunit of cyclin-dependent kinases (CDK) 4 and 6, is required for, and capable of, shortening, the G j phase of the cell cycle through the formation of holoenzyme complexes (cyclin-CDK) that phosphorylate retinoblastoma protein (pRB).
Derek F. Amanatullah +6 more
openaire +3 more sources