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Cyclin D1 overexpression in hepatocellular carcinoma
Liver, 2001Abstract: Background/Aims: Cyclin D1 gene amplification and cyclin D1 protein overexpression have been reported in various human tumors, including hepatocellular carcinoma (HCC). However, their significance is still controversial. In the present study, we examined the expression of cyclin D1 and its relationships to p53 and Ki‐67 in HCCs. Methods: The
Yun Kyung Kang +4 more
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Implication of Cyclin D1 in Malignant Lymphoma
Critical Reviews™ in Oncogenesis, 1996The chromosomal translocation t(11;14)(q13;q32) is observed in a number of lymphoid malignancies but is specifically associated with a particular subtype of non-Hodgkin's lymphoma called mantle cell lymphoma, where it is observed in up to 70% of cases. This translocation juxtaposes IGH sequences at 14q32 to a region variously termed BCL1/PRAD1 at 11q13,
Dominique Leroux +3 more
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Cyclin D1 transcriptional activation in MCL
Blood, 2014In this issue of Blood, Allinne et al propose the nucleolin-dependent activation of the translocated CCND1 allele in mantle cell lymphoma (MCL) because of its relocalization to a transcriptionally favorable area in the perinucleolar region.
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Deregulation of Cyclin D1 in Cancer
1998Cell cycle progression in eukaryotic cells is governed by a series of cyclins and cyclin dependent kinases. Individual cyclins act at different phases of the cell cycle by binding and stimulating the activities of cdk’s. Because these cyclins and cdk’s are pivotal to cell cycle control and thereby cell proliferation, mutational changes and alterations ...
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Cyclin D1 in Human Neuroendocrine: Tumorigenesis
Annals of the New York Academy of Sciences, 2004Abstract: Human neuroendocrine tumors exhibit unique biological properties, and defining the molecular genetic alterations that underlie these distinctive features remains an important challenge. In addition to the MEN1 tumor suppressor gene, the cyclin D1 oncogene has demonstrated a role in the pathogenesis of parathyroid and gastroenteropancreatic ...
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Cyclin D1 Transgenic Mouse Models
2002G1 cyclins influence whether initiation of a new cell cycle occurs. Expression of these cyclins is cell-cycle-phase dependent and regulated transcriptionally, post-transcriptionally and post-translationally (1–4). In addition, distinct human cyclin-dependent kinases—cdks—have been identified that associate with cyclins and share extensive amino-acid ...
Hiroshi Nakagawa +2 more
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