Results 111 to 120 of about 1,222,938 (291)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Mechanical Side-Deep Fertilization Synergizes with Controlled-Release Fertilizer to Drive Low-Carbon and High-Efficiency Rice (Oryza sativa L.) Production

Agriculture
Against the backdrop of escalating global climate challenges, minimizing carbon emissions while enhancing energy efficiency in rice production has emerged as a core pathway toward achieving agricultural carbon neutrality. A two-year field study conducted
Manman Yuan, Jiabao Wang, Gang Wu, Jian Jin, Yegong Hu, Chuang Liu, Qi Miao, Pingping Wu, Yixiang Sun   +8 more
doaj   +1 more source

Spectroscopy of a narrow-line laser cooling transition in atomic dysprosium

, 2010
The laser cooling and trapping of ultracold neutral dysprosium has been recently demonstrated using the broad, open 421-nm cycling transition. Narrow-line magneto-optical trapping of Dy on longer wavelength transitions would enable the preparation of ...
Benjamin L. Lev, C. Cohen-Tannoudji, D. Budker, H. J. Metcalf, I. I. Sobelman, Mingwu Lu, Seo Ho Youn, W. C. Martin, W. Demtröder   +8 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Changes in ultrasound and bioelectrical-derived body composition parameters in response to training load during pre-season in professional male road cyclists

BMC Sports Science, Medicine and Rehabilitation
Purpose The pre-season is commonly a period during which cyclists implement interventions to optimize performance, training, and body composition. Ultrasonography and bioelectrical impedance vector analysis (BIVA) can serve as efficient methods to track ...
Andrea Giorgi, Francesco Campa, Martino V. Franchi, Maurizio Vicini, Borja Martinez-Gonzalez   +4 more
doaj   +1 more source

The acute effect of whole-body vibration on cycling peak power output [PDF]

, 2013
The aim of the present study was to determine if an acute bout of whole-body vibration (WBV) prior to sprint cycling would increase peak power output.
Hill, Colin
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Self‐assembled monolayers for perovskite solar cells

Information & Functional Materials
In metal‐halide perovskite solar cells (PSCs), various carrier recombination losses occur at the interface between metal oxides (MOs) and perovskite (PVK) due to the imperfect lattice structure of the crystal surface.
Dongdong Xu, Pu Wu, Hairen Tan
doaj   +1 more source

Lamination residual stresses in fiber composites [PDF]

An experimental investigation was conducted to determine the magnitude of lamination residual stresses in angle-ply composites and to evaluate their effects on composite structural integrity.
Daniel, I. M., Liber, T.
core   +1 more source