Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai +8 more
wiley +1 more source
Seasonal variations drive microbial community structure and nitrogen cycling in sediments of tributary pumping station forebays. [PDF]
Wei X, Song W, Li S.
europepmc +1 more source
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley +1 more source
Dual Soft-Gel Electrodes Enabling Near-Practical and Deployable Aqueous Batteries. [PDF]
Zhang K +5 more
europepmc +1 more source
Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão +3 more
wiley +1 more source
Assessment of the influence of lower limb cycling on arm muscle coordination during upper limb cycling: a pilot study. [PDF]
Botzheim L +5 more
europepmc +1 more source
Eccentric Cycling Improves Motor Learning More Than Concentric Cycling. [PDF]
Youssef L, Pageaux B, Neva JL.
europepmc +1 more source
Environmental determinants of hiking, jogging, and cycling along the Beijing-Tianjin-Hebei grand canal: implications for health promotion. [PDF]
Cai Z, Yu Y, Lu M.
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TIME-RESTRICTED EATING IN MASLD: THE IMPERATIVE TO PRESERVE MUSCLE MASS AND PREVENT WEIGHT CYCLING FOR SUSTAINABLE CLINICAL BENEFIT. [PDF]
Ketenci YB, Demiröz H, Akca M.
europepmc +1 more source

