Results 301 to 310 of about 141,408 (359)

Analysis of nondegradable cyclins reveals distinct roles of the mitotic cyclins in Drosophila meiosis. [PDF]

G3 (Bethesda)
Bourouh M, Dhaliwal R, Rai R, Qureshi H, Swan A.   +4 more
europepmc   +1 more source

Targeting the Menin–KMT2A interaction in leukemia: Lessons learned and future directions

International Journal of Cancer, EarlyView.
Abstract Chromosomal rearrangements involving the Mixed Lineage Leukemia gene (MLL1, KMT2A) are defining a genetically distinct subset in about 10% of human acute leukemias. Translocations involving the KMT2A‐locus at chromosome 11q23 are resulting in the formation of a chimeric oncogene, where the N‐terminal part of KMT2A is fused to a variety of ...
Florian Perner, Jayant Y. Gadrey, Scott A. Armstrong, Michael W. M. Kühn   +3 more
wiley   +1 more source

RHOB regulates megakaryocytic and erythroid differentiation by altering the cell cycle and cytoskeleton. [PDF]

Sci Rep
Liu P, Yuan X, Liu Y, Guo M, Xu L, Dong Q, Fan T, Lv Y, Pei X, Qu M, Yue W, Xie X.   +11 more
europepmc   +1 more source

Therapeutic targeting of chromatin alterations in leukemia and solid tumors

International Journal of Cancer, EarlyView.
Abstract Alterations in chromatin conformation and post‐translational modification of histones have become increasingly recognized as critical drivers of cancer development, progression, and therapy resistance. Recent advances in drug development have led to the establishment of several highly selective small molecule inhibitors, several of which are ...
Florian Perner, Tobias Berg, Daniel Sasca, Sophie‐Luise Mersiowsky, Jayant Y. Gadrey, Johanna Thomas, Michael W. M. Kühn, Michael Lübbert   +7 more
wiley   +1 more source

The Role of Ayurveda in Prostate Cancer Management. [PDF]

Integr Cancer Ther
Jabbari P, Yazdanpanah O, Benjamin DJ, Rezazadeh Kalebasty A.   +3 more
europepmc   +1 more source

Cyclosporine A causes gingival overgrowth via reduced G1 cell cycle arrest in gingival fibroblasts. [PDF]

PLoS One
Takeuchi R, Nomura T, Yaguchi M, Kuwahara N, Amino Y, Taguchi C, Suzuki I, Suzuki H, Nagashima T, Arikawa K, Okada Y, Nomoto T, Hiratsuka K.   +12 more
europepmc   +1 more source

Molecular subtyping and precision therapy for esophageal cancer

Interdisciplinary Medicine, EarlyView.
The molecular typing of esophageal cancer based on genome, transcriptome, proteome, and multi‐omics revealed various molecular features and provided potential targets for the precision therapy. Recent trials have shown that immunotherapy or molecular targeted therapy plus chemoradiotherapy can improve overall survival and progression‐free survival in ...
Guangkun Pei, Zhuoran Liang, Bianli Gu, Linlin Shi, Ze‐Xian Liu, Shegan Gao   +5 more
wiley   +1 more source

Folate depletion impact on the cell cycle results in restricted primary root growth in Arabidopsis. [PDF]

Plant Mol Biol
De Lepeleire J, Mishra RC, Verstraete J, Pedroza Garcia JA, Stove C, De Veylder L, Van Der Straeten D.   +6 more
europepmc   +1 more source

Anti-lymphoma peptide is inspired by mapping a sequence of four amino acids of KRAI motif as nuclear localization signal of Crlz-1. [PDF]

Mol Ther Oncol
Pi JH, Choi SY, Park SK, Lim J, Kang CJ.
europepmc   +1 more source

microRNA‐Mediated Regulation of Oxidative Stress in Cardiovascular Diseases

Journal of Clinical Laboratory Analysis, EarlyView.
ABSTRACT Background Cardiovascular diseases (CVDs) are the leading cause of mortality globally, often linked to oxidative stress. MicroRNAs (miRNAs) have emerged as significant regulators of oxidative stress within the cardiovascular system. Objective This review examines the complex relationship between miRNAs and oxidative stress, clarifying their ...
Sakhavat Abolhasani, Yasin Ahmadi, Davood Fattahi, Yavar Rostami, Khalil Maleki Chollou   +4 more
wiley   +1 more source