Results 191 to 200 of about 42,214 (296)

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

No Detectable Effect of Caffeine Expectancy Induced by a Placebo Capsule on Time to Exhaustion at the Respiratory Compensation Point in Trained Cyclists. [PDF]

Sports (Basel)
Valero F, González-Mohíno F, Alda-Blanco A, Muñoz de la Cruz V, Rodríguez-Barbero S, Galán-Rioja MÁ, Salinero JJ.   +6 more
europepmc   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

E-scooter riders sustain more head and internal injuries than motorcyclists and cyclists in England and Wales. [PDF]

Sci Rep
Kungwengwe G, Gach MW, Gowda S, Tandanu E, Donnachie D, Menkin Z, Sandhar S, Bodansky D.   +7 more
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Beyond Ergogenic Effects: Limited Evidence on Caffeine-Related Problematic Use, Dependence, and Withdrawal in Athletic Populations-A Structured Narrative Review. [PDF]

Nutrients
Liu H, Cao Y, Zhang G, Li H.
europepmc   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Case-control study of fatal bicycle crashes in peri-urban areas of Delhi. [PDF]

Inj Prev
Paturi R, Agrawal S, Bilam S, Bhalla K, Goel R.   +4 more
europepmc   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Cardiac remodeling and myocardial late gadolinium enhancement in competitive amateur cyclists: insights from cardiac MRI. [PDF]

Int J Cardiovasc Imaging
Albrecht F, Thottakara T, Schaerk J, Welsch GH, Münch J, Pressler A, Reeder SB, Patten M, Lund GK, Starekova J.   +9 more
europepmc   +1 more source