Redox Reorganization: Aluminium Promoted 1,5-Hydride Shifts Allow the Controlled Synthesis of Multisubstituted Cyclohexenes. [PDF]
Angew Chem Int Ed Engl, 2023 An efficient synthesis of cyclohexenes has been achieved from easily accessible tetrahydropyrans via a tandem 1,5‐hydride shift–aldol condensation. We discovered that readily available aluminium reagents, e.g.
Smith LB +8 more
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Phenyl Sulfones: A Route to a Diverse Family of Trisubstituted Cyclohexenes from Three Independent Nucleophilic Additions. [PDF]
J Am Chem Soc, 2022 A novel process is described for the synthesis of di- and trisubstituted cyclohexenes from an arene. These compounds are prepared from three independent nucleophilic addition reactions to a phenyl sulfone (PhSO2R; R = Me, Ph, and NC4H8) dihapto ...
Simpson SR +9 more
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The double protonation of dihapto-coordinated benzene complexes enables dearomatization using aromatic nucleophiles [PDF]
Nature Communications, 2023 Friedel-Crafts Arylation (the Scholl reaction) is the coupling of two aromatic rings with the aid of a strong Lewis or Brønsted acid. This historically significant C–C bond forming reaction normally leads to aromatic products, often as oligomeric ...
Justin T. Weatherford-Pratt +7 more
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Tungsten-anisole complex provides 3,6-substituted cyclohexenes for highly diversified chemical libraries. [PDF]
Sci AdvMedicinal chemists use vast combinatorial molecular libraries to develop leads for new pharmaceuticals. The syntheses of these compounds typically rely on coupling molecular fragments through atoms with planar (sp2) geometry.
Weatherford-Pratt JT +12 more
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Polyoxygenated Cyclohexenes from Uvaria grandiflora with Multi-Enzyme Targeting Properties Relevant in Type 2 Diabetes and Obesity. [PDF]
ACS Omega, 2022 Shikimic acid-derived polyoxygenated cyclohexene natural products commonly occurring in several species of the Uvaria represent natural products with promising biological activities.
Quimque MTJ +7 more
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Highly oxygenated cyclohexenes from the leaves of Uvaria grandiflora Roxb. ex Hornem and their cytotoxic and α-glucosidase inhibitory activities [PDF]
HeliyonPhytochemical investigation of the leaf extract of Uvaria grandiflora Roxb. ex Hornem led to the isolation and identification of two new highly oxygenated cyclohexenes, uvariagrandols A (1) and B (2), together with seven known compounds (3–9).
Virayu Suthiphasilp +13 more
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Palladium-catalyzed enantioselective β-hydride elimination for the construction of remote stereocenters [PDF]
Nature CommunicationsThe β-H elimination is a crucial elementary step in transition-metal catalysis, but controlling the stereochemistry of this process has been underdeveloped.
Shaozi Sun, Shengnan Sun, Weiwei Zi
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Approaches to the Total Synthesis of Conduramines: A Review
SynOpen, 2022 This review reports on the total synthesis of conduramines, which are formally derived from conduritols, mainly containing a trihydroxy aminocyclohexene core.
Hanumantharayappa Bharathkumar +3 more
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A new finding in the old Knoevenagel condensation reaction
Results in Chemistry, 2022 Reaction of benzaldehyde (5a) with defined quantities of ethyl cyanoacetate (6) in presence of piperidine was studied. In a neat condition, hexasubstituted cyclohexeneamine (7a) with three ester substituents was formed along with ethyl acrylate (9a ...
Attimogee Shivamurthy Harisha +5 more
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