A–C Estrogens as Potent and Selective Estrogen Receptor-Beta Agonists (SERBAs) to Enhance Memory Consolidation under Low-Estrogen Conditions [PDF]
, 2018 Estrogen receptor-beta (ERβ) is a drug target for memory consolidation in postmenopausal women. Herein is reported a series of potent and selective ERβ agonists (SERBAs) with in vivo efficacy that are A–C estrogens, lacking the B and D estrogen rings ...
Donaldson, William A. +12 more
core +4 more sources
Advanced Intelligent Discovery, EarlyView.This work introduces a novel framework for identifying non‐small cell lung cancer biomarkers from hundreds of volatile organic compounds in breath, analyzed via gas chromatography‐mass spectrometry. This method integrates generative data augmentation and multi‐view feature selection, providing a stable and accurate solution for biomarker discovery in ...
Guancheng Ren +10 more
wiley +1 more source
MoleculesDue to the importance of biaryls as natural products, drugs, agrochemicals, dyes, or organic electronic materials, a green alternative biaryl synthesis has been developed based on easy-to-prepare and cheap copper(I)-exchanged zeolite catalysts.
Xiaohui Di +7 more
doaj +1 more source
Aziridine-Metathesis based Approaches to Alkaloid Synthesis [PDF]
, 2009 The aim of the project is to synthesise (-)-morphine utilising aziridine and metathesischemistry. The thesis is divided into three chapters.Chapter 1 provides brief reviews on the subjects of total synthesis of morphine; ringrearrangementmetathesis (RRM)
Lu, Pengfei, Lu, Pengfei
core +2 more sources
Frontiers in PharmacologyIntroduction: Due to its highly aggressiveness and malignancy, glioblastoma (GBM) urgently requires a safe and effective treatment strategy. Zeylenone, a natural polyoxygenated cyclohexenes compound isolated from Uvaria grandiflora, has exhibited ...
Rui Su +10 more
doaj +1 more source
Cleavage of the Oxanorbornene Oxygen Bridge with Lewis Acids: Computation and Experiment [PDF]
, 2009 Since the discovery of the biological activity of aminophosphonates, research started on the synthesis of more constraint azaheterocyclic phosphonates. We developed a route via an intramolecular Diels-Alder reaction towards α-aminophosphonates 1. [1] The
Claeys, Diederica +6 more
core +1 more source
Biological Properties of Vitex agnus-castus Essential Oil (Phytochemical Component, Antioxidant and Antifungal Activity) [PDF]
, 2015 Background: Vitex agnus-castus is a deciduous shrub that is native to the Mediterranean region. It has traditionally been used in Iranian medicine.
Emami, Seyed Jamal +4 more
core +1 more source
The low temperature solvent-free aerobic oxidation of cyclohexene to cyclohexane diol over highly active Au/Graphite and Au/Graphene catalysts [PDF]
, 2018 The selectivity and activity of gold-catalysts supported on graphite and graphene have been compared in the oxidation of cyclohexene. These catalysts were prepared via impregnation and sol immobilisation methods, and tested using solventless and radical ...
Engel, Rebecca +6 more
core +2 more sources
Organophotoredox/Cobalt‐Catalyzed Retro‐Hydroformylation of Aldehydes
ChemistryEurope, EarlyView.A new photoredox/cobalt retro‐hydroformylation is developed. This one‐pot two‐step process involves the in situ formation of the corresponding 1,4‐dihydropyridine as key intermediate. Under mild reaction conditions, alkenes are efficiently produced from a wide range of aliphatic α‐monosubstituted aldehydes, with high functional‐group tolerance.
Augustin Nouaille +3 more
wiley +1 more source
The influence of reaction conditions on the Diels-Alder cycloadditions of 2-thio-3-chloroacrylamides; investigation of thermal, catalytic and microwave conditions [PDF]
, 2010 The Diels-Alder cycloadditions of cyclopentadiene and 2,3-dimethyl-1,3-butadiene to a range of 2-thio-3-chloroacrylamides under thermal, catalytic and microwave conditions is described.
Chopra, Jay +4 more
core +1 more source