Spirocyclic Diamine Scaffolds for Medicinal Chemistry
Helvetica Chimica Acta, Volume 109, Issue 1, January 2026.Here we enumerated 391 spirocyclic diamine drug scaffolds with ring sizes four to eight and found that most of them are unknown. We prepared four novel such spirocycles and discovered a micromolar inhibitor of the M4 muscarinic receptor. ABSTRACT Medicinal chemistry requires the exploration of structurally diverse compound families to expand the ...
Aline Carrel +3 more
wiley +1 more source
Dual‐Fluorophore Labeling for Polymer Blending Differentiation and Visualization
Aggregate, Volume 6, Issue 12, December 2025.This work employs a dual fluorescent labeling strategy to visualize phase separation in polymer blends. Using confocal laser scanning microscopy, distinct phase separation is clearly observed in the absence of a compatibilizer. This phenomenon disappears upon compatibilizer addition, demonstrating the strategy's effectiveness in monitoring blend ...
Zhikang Xie, Siyu Yi, Xiangcheng Pan
wiley +1 more source
Visible‐Light Mediated Activation of 1,3‐Dienes and Allenes via Energy Transfers
Chemistry – A European Journal, Volume 31, Issue 67, December 1, 2025.Nature has inspired chemists to develop photocatalytic processes that harness visible light, offering alternative reaction pathways beyond traditional thermal methods. Energy Transfer (EnT) is a particularly promising strategy, enabling transformations such as isomerization, deracemization, cycloadditions, and cascade reactions.
Scarica Gabriele +6 more
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European Journal of Lipid Science and Technology, Volume 127, Issue 12, December 2025.GRAPHICAL ABSTRACT Preparation of W/O/W double emulsions using hydrophobic silica (R972) and maltodextrin. A primary W/O emulsion is formed via homogenization and ultrasound and then re‐emulsified in an outer aqueous phase. The final emulsion is freeze‐dried for 1 day to obtain structured antibubbles.
Charalampos Tsekeridis +3 more
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Pest Management Science, Volume 81, Issue 10, Page 6911-6927, October 2025.Terpenoid compounds from the essential oil of Artemisia austriaca, particularly camphor and 1,8‐cineole, infiltrate seed tissues and impede the germination of Avena fatua (wild oat) seeds by disrupting gibberellic acid and abscisic acid levels, as well as inhibiting critical enzymes involved in starch, lipid and protein metabolism.
Mohammad Pouresmaeil +4 more
wiley +1 more source
Research Progress on Pharmacological Effects of Key Pharmacodynamic Material Basis Components of <i>Schisandrae chinensis</i> Fructus. [PDF]
J Microbiol BiotechnolPan H +6 more
europepmc +1 more source
Case Commentary: Successful Use of Cefepime/Zidebactam (WCK 5222) as a Salvage Therapy for the Treatment of Disseminated Extensively Drug-Resistant New Delhi Metallo-β-Lactamase-Producing Pseudomonas aeruginosa Infection in an Adult Patient with Acute T-Cell Leukemia. [PDF]
Antimicrob Agents Chemother, 2023 Egge SL, Lewis JS, Hakki M.
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ChemInform Abstract: Efficient Route to Optically Pure Polyfunctionalized Cyclooctanes.
, 2002 Yves Le Merrer +2 more
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Click to Translate: Synthesis of Trans-Cyclooctene Modified 5' mRNA Caps for Bioorthogonal Activation. [PDF]
ChembiochemZips N, Kulko E, Kath-Schorr S.
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Comparative <i>in vitro</i> efficacy of aztreonam-avibactam and other alternatives (cefepime-taniborbactam, cefepime-zidebactam, and cefiderocol) against metallo-β-lactamase-producing Enterobacterales isolated in 2024 in France. [PDF]
Antimicrob Agents ChemotherEmeraud C, Dutkiewicz M, Dortet L.
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