Results 61 to 70 of about 378,238 (343)

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

A nested cohort study of 6,248 early breast cancer patients treated in neoadjuvant and adjuvant chemotherapy trials investigating the prognostic value of chemotherapy-related toxicities. [PDF]

, 2015
BACKGROUND: The relationship between chemotherapy-related toxicities and prognosis is unclear. Previous studies have examined the association of myelosuppression parameters or neuropathy with survival and reported conflicting results.

core   +2 more sources

Allergic granulomatous angiitis [PDF]

Vojnosanitetski Pregled, 2004
Allergic granulomatous angiitis (AGA) - Churg-Strauss syndrome, is a rare autoimmune disease characterized by three distinct clinical phases prodromal, eosinophilic, and vasculitic, and most of respiratory symptoms and signs begin in the first two phases
Trifunović Gordana, Plavec Goran, Tomić Ilija, Popović Lidija, Stefanović Dušan   +4 more
doaj   +1 more source

Working Towards a Treat-to-Target Protocol in Juvenile Proliferative Lupus Nephritis – A Survey of Pediatric Rheumatologists and Nephrologists in Germany and Austria

Frontiers in Pediatrics, 2022
BackgroundTo describe treatment practices for juvenile proliferative lupus nephritis (LN) class III and IV of pediatric rheumatologists and nephrologists in Germany and Austria in preparation for a treat-to-target treatment protocol in LN.MethodsSurvey ...
Kristina Vollbach, Catharina Schuetz, Christian M. Hedrich, Christian M. Hedrich, Fabian Speth, Kirsten Mönkemöller, Jürgen Brunner, Ulrich Neudorf, Christoph Rietschel, Anton Hospach, Tilmann Kallinich, Claas Hinze, Norbert Wagner, Burkhard Tönshoff, Lutz T. Weber, Kay Latta, Julia Thumfart, Martin Bald, Dagobert Wiemann, Hildegard Zappel, Klaus Tenbrock, Dieter Haffner   +21 more
doaj   +1 more source

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

Life‐Threatening Bradycardia in Anti‐NMDA‐Receptor Encephalitis and a Novel Use for Permanent Pacing

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Pediatric anti‐NMDA receptor encephalitis (pNMDARE) is an autoantibody‐mediated disorder that can cause severe autonomic dysfunction, including symptomatic bradycardia and asystole. Dysautonomia can last for years, making it very challenging to manage.
Sarah Tucker, Abhijit Das, Andres Jimenez, Areeba Basit, Yike Jiang, Emily A. Smitherman, Heather Van Mater, Taylor Howard, Alexander J. Sandweiss, Kristen S. Fisher   +9 more
wiley   +1 more source

Advances in the design and development of oncolytic measles viruses. [PDF]

, 2015
A successful oncolytic virus is one that selectively propagates and destroys cancerous tissue without causing excessive damage to the normal surrounding tissue. Oncolytic measles virus (MV) is one such virus that exhibits this characteristic and thus has
Hutzen, Brian, Raffel, Corey, Studebaker, Adam W   +2 more
core   +1 more source

Haploidentical Stem Cell Transplantation With Posttransplant Cyclophosphamide Therapy vs Other Donor Transplantations in Adults With Hematologic Cancers: A Systematic Review and Meta-analysis.

JAMA Oncology, 2019
Importance Use of haploidentical (HAPLO) stem cell transplantation with posttransplant cyclophosphamide is rapidly increasing in adults with hematologic cancers.
N. Gagelmann, A. Bacigalupo, A. Rambaldi, D. Hoelzer, J. Halter, J. Sanz, F. Bonifazi, E. Meijer, M. Itälä-Remes, M. Marková, C. Solano, N. Kröger   +11 more
semanticscholar   +1 more source

Behaviour of oligodendrocytes and Schwann cells in an experimental model of toxic demyelination of the central nervous system Comportamento de oligodendrócitos e células de Schwann em modelo experimental de desmielinização tóxica do sistema nervoso central

Arquivos de Neuro-Psiquiatria, 2001
Oligodendrocytes and Schwann cells are engaged in myelin production, maintenance and repairing respectively in the central nervous system (CNS) and the peripheral nervous system (PNS).
Dominguita Lühers Graça, Eduardo Fernandes Bondan, Luis Antonio Violin Dias Pereira, Cristina Gevehr Fernandes, Paulo César Maiorka   +4 more
doaj   +1 more source

A Personalized Rituximab Retreatment Approach Based on Clinical and B-Cell Biomarkers in ANCA-Associated Vasculitis

Frontiers in Immunology, 2022
BackgroundTime to relapse after rituximab for the treatment of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is variable, and optimal retreatment strategy has remained unclear.
Jack Arnold, Edward M. Vital, Edward M. Vital, Shouvik Dass, Shouvik Dass, Aamir Aslam, Aamir Aslam, Andy C. Rawstron, Sinisa Savic, Sinisa Savic, Paul Emery, Paul Emery, Md Yuzaiful Md Yusof, Md Yuzaiful Md Yusof   +13 more
doaj   +1 more source