Results 221 to 230 of about 5,815 (271)

Interlaboratory comparison trial on cylindrospermopsin measurement

Analytical Biochemistry, 2004
The hepatotoxin cylindrospermopsin (CYN) is a potent inhibitor of protein synthesis in mammalian cells. It is produced by freshwater cyanobacterial blooms in countries such as Australia, the United States, Israel, Thailand, and Brazil. An interlaboratory comparison was organized as a first step to evaluate the measurement of CYN in lyophilized ...
Andrea, Törökné, Maria, Asztalos, Maria, Bánkiné, Heike, Bickel, Georg, Borbély, Shmuel, Carmeli, Geoffrey A, Codd, Jutta, Fastner, Qiong, Huang, Andrew, Humpage, James S, Metcalf, Erzsebet, Rábai, Assaf, Sukenik, Gyula, Surányi, Gabor, Vasas, Viktor, Weiszfeiler   +15 more
openaire   +2 more sources

The Cylindrospermopsin Alkaloids

2011
Abstract The cylindrospermopsin alkaloids are a family of structurally similar toxic natural products first encountered with the isolation of cylindrospermopsin from the cyanobacterium Cylindrospermopsis raciborskii , which was the causative agent in the poisoning of 148 inhabitants of Palm Island, Australia.
Daniel M, Evans, Patrick J, Murphy
openaire   +2 more sources

Syntheses of the cylindrospermopsin alkaloids

Tetrahedron, 2006
Abstract An intramolecular 1,3-dipolar cycloaddition has efficiently constructed the A-ring portions of the cylindrospermopsin alkaloids. A nitro-aldol addition of an elaborated nitroalkane to a pyrimidine aldehyde followed by an intramolecular reductive guanidinylation has enabled the syntheses of all three alkaloids in this family in 18–19 steps ...
Ryan E. Looper, Maria T.C. Runnegar, Robert M. Williams   +2 more
openaire   +1 more source

Genotoxicity investigation of a cyanobacterial toxin, cylindrospermopsin

Toxicon, 2002
Cylindrospermopsin (CYN), a potent cyanobacterial hepatotoxin produced by Cylindrospermopsis raciborskii and other cyanobacteria, is regularly found in water supplies in many parts of the world, and has been associated with the intoxication of humans and livestock.
Shen, X. Y., Lam, P. K. S., Shaw, G. R., Wickramasinghe, W.   +3 more
openaire   +3 more sources

Electrochemical Investigation of DNA Interactions with Cyanobacterial Toxins: Cylindrospermopsin and Saxitoxin

ChemistrySelect
Anthropogenic eutrophication threatens freshwater sources used for agricultural irrigation and increases the occurrence risk of cyanotoxins, such as cylindrospermopsin (CYN) and saxitoxin (STX).
Ece Kesici‐Meco, Mete Yilmaz, Ece Unur‐Yilmaz   +2 more
semanticscholar   +1 more source

Total Synthesis of rac‐Cylindrospermopsin

ChemInform, 2005
AbstractFor Abstract see ChemInform Abstract in Full Text.
Barry B. Snider, Chaoyu Xie
openaire   +1 more source

Cylindrospermopsin exposure promotes redox unbalance and tissue damage in the liver of Poecilia reticulata, a neotropical fish species

Journal of Toxicology and Environmental Health, Part A, 2023
There is a growing concern regarding the adverse risks exposure to cylindrospermopsin (CYN) might exert on animals and humans. However, data regarding the toxicity of this cyanotoxin to neotropical fish species are scarce. Using the fish species Poecilia
Simone Maria Teixeira de Sabóia-Morais, João Marcos de Lima Faria, Jéssica Custódio da Silva Rabelo, A. L. Hanusch, L. A. Mesquita, Raquel de Andrade Silva, J. M. de Oliveira, L. W. O. de Jesus   +7 more
semanticscholar   +1 more source

Cytotoxicity Screening for the Cyanobacterial Toxin Cylindrospermopsin

Journal of Toxicology and Environmental Health, Part A, 2009
The cell lines C3A, HepG2, NCI-87, HCT-8, HuTu-80, Caco-2, and Vero were screened for sensitivity to the cyanobacterial toxin cylindrospermopsin (CYN), with the aim of determining the most sensitive cells to be used in cytotoxicity tests. Cell lines were chosen to be representative of the organs targeted by the toxin; liver, kidney, intestine, and were
Froscio, S., Fanok, S., Humpage, A.
openaire   +3 more sources

Sustainable and Sensitive Aptasensor for Detection of Cylindrospermopsin Using Conductive Polymer PEDOT:PSS

ChemistrySelect
Cyanotoxins, produced by cyanobacteria, pose serious genotoxic, hepatotoxic, nephrotoxic, and neurotoxic risks in aquatic ecosystems. Among these, cylindrospermopsin (CYN), known for its high water solubility and bioaccumulation potential, significantly ...
Ece Kesici‐Meco, Ece Unur‐Yilmaz
semanticscholar   +1 more source

ChemInform Abstract: The Cylindrospermopsin Alkaloids

ChemInform, 2012
AbstractReview: 209 refs.
Daniel M. Evans, Patrick J. Murphy
openaire   +1 more source