Results 31 to 40 of about 40,704 (273)

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2C19 and Proton Pump Inhibitor Dosing

Clinical pharmacology and therapy, 2020
Proton pump inhibitors (PPIs) are widely used for acid suppression in the treatment and prevention of many conditions, including gastroesophageal reflux disease, gastric and duodenal ulcers, erosive esophagitis, Helicobacter pylori infection, and ...
J. Lima, Cameron D Thomas, Julia M. Barbarino, Z. Desta, S. V. Van Driest, Nihal El Rouby, Julie A. Johnson, L. Cavallari, V. Shakhnovich, D. L. Thacker, S. Scott, M. Schwab, C. Uppugunduri, Christine M. Formea, J. Franciosi, K. Sangkuhl, A. Gaedigk, T. Klein, Roseann S. Gammal, T. Furuta   +19 more
semanticscholar   +1 more source

Cost-effectiveness of CYP2C19 genotyping to guide antiplatelet therapy for acute minor stroke and high-risk transient ischemic attack

Scientific Reports, 2021
Dual antiplatelet therapy (DAPT) with clopidogrel plus aspirin within 48 h of acute minor strokes and transient ischemic attacks (TIAs) has been indicated to effectively reduce the rate of recurrent strokes.
Zeling Cai, De Cai, Ruiwen Wang, Heng Wang, Ze Yu, Fei Gao, Yuansheng Liu, Yingbo Kang, Zhuomin Wu   +8 more
semanticscholar   +1 more source

Evaluation of changes in cytochrome P450 2C19 activity in type 2 diabetic rats before and after treatment, by using isolated perfused liver model [PDF]

Iranian Journal of Basic Medical Sciences, 2020
Objective(s): Alteration in drug metabolism is very likely in diabetes mellitus. This study assessed changes in CYP2C19 enzymatic activity in the liver using omeprazole as a probe in the animal model of type II diabetes (T2DM) before and after treatment ...
Navid Neyshaburinezhad, Mohammad Reza Rouini, Hanieh Entezari, Hoda Lavasani, Yalda Hosseinzadeh Ardakani   +4 more
doaj   +1 more source

CYP2C19*1 and CYP2C19*2 Polymorphism in Turkish Patients Being Diagnosed with Stable Coronary Artery Disease and Using Clopidogrel

Bagcilar Medical Bulletin, 2021
Objective:The CYP2C19*1 has an entirely normal activity allele whose clopidogrel metabolism is normal. CYP2C19*2 called as non-functional alleles. In this study, we aimed to establish the CYP2C19*1 and CYP2C19*2 genotype frequencies both in Turkish ...
Ramazan Sabırlı, Aylin Köseler, Atakan Yılmaz, İsmail Doğu Kılıç   +3 more
doaj   +1 more source

Association between CYP2C9 and CYP2C19 Polymorphism, Metabolism, and Neurotoxicity after Administration of Phenytoin: A Systematic Review

Keluwih, 2023
—Phenytoin is an antiepileptic drug (AED) metabolized by cytochrome P450 enzymes, especially by CYP2C9 (90%) and CYP2C19 (10%), where both enzymes are polymorphic so that they can undergo polymorphism and it can change the metabolic rate of the drug ...
Rizka Mardhiani, Yahdiana Harahap, Winnugroho Wiratman   +2 more
doaj   +1 more source

Metabolic activation of aegeline mediated by CYP2C19

Xenobiotica, 2021
Aegeline (AGL) is a natural alkaloidal amide mainly isolated from the leaves and fruits of tropical plant Aegle marmelos, with multiple pharmacological activities.As one component of several dietary supplements, AGL caused a series of acute and chronic liver injuries. Nevertheless, the mechanisms of AGL-induced hepatotoxicity remain unclear. This study
Wei Li, Min Tian, Lan Yang, Jiang Zheng, Jiaru Li, Ying Peng, Shenzhi Zhou   +6 more
openaire   +3 more sources

Association of CYP2C19 and CYP2D6 Poor and Intermediate Metabolizer Status With Antidepressant and Antipsychotic Exposure: A Systematic Review and Meta-analysis.

JAMA psychiatry, 2020
Importance Precise estimation of the drug metabolism capacity for individual patients is crucial for adequate dose personalization. Objective To quantify the difference in the antipsychotic and antidepressant exposure among patients with genetically ...
Filip Milosavljević, N. Bukvić, Z. Pavlovic, Č. Miljević, V. Pešić, E. Molden, M. Ingelman-Sundberg, S. Leucht, M. Jukic   +8 more
semanticscholar   +1 more source

Cypc19*17 Polymorphism as a Risk-factor for Nsaids-induced Ulcers [PDF]

, 2016
The new risk-factors for peptic ulcers induced by the use of nonsteroidal antiinflammatory drugs, such as polymorphism of different isoenzymes of cytochrome P450 were considered in the article.
Balabanseva, A. (Alexandra), Onischuk, L. (Lyudmyla), Tkach, S. (Serhiy)   +2 more
core   +2 more sources

Impaired hepatic drug and steroid metabolism in congenital adrenal hyperplasia due to P450 oxidoreductase deficiency [PDF]

, 2010
Objective: Patients with congenital adrenal hyperplasia due to P450 oxidoreductase (POR) deficiency(ORD) present with disordered sex development and glucocorticoid deficiency.
Arlt, Bebia, Chang, de Morais, Dominique Maiter, Dorota Tomalik-Scharte, Fl  ck, Fuhr, Gomes, Hannah E Ivison, Henderson, Jetter, Julia Kirchheiner, Kelley, Kirchheiner, Kranendonk, Nebert, Nicolo, Parkinson, Porter, Ribes, Sachse, Tantcheva-Po  r, Tomalik-Scharte, Uwe Fuhr, Wiebke Arlt   +25 more
core   +2 more sources

CYP2C19 genotype and the PPIs – focus on rabeprazole [PDF]

Journal of Gastroenterology and Hepatology, 2005
Abstract: Amongst all the proton pump inhibitors (PPI), the hepatic metabolism of rabeprazole is least dependent on the CYP4502C19 system. Rabeprazole is therefore the PPI least affected by CYP4502C19 genetic polymorphism. This unique feature of rabeprazole complements rabeprazole's fast onset of action, and may lead to profound and consistent ...
Goh, KL, Wong, BCY, Lim, PWY
openaire   +4 more sources