Results 91 to 100 of about 15,566 (231)

Association of CYP3A4 and CYP3A5 polymorphisms with Iranian breast cancer patients

Egyptian Journal of Medical Human Genetics, 2015
Background: Polymorphisms of different gene have been reported to be associated with cancer including breast cancer. Hospitalization rate for breast cancer has increased over the years in Iran.
Elham Badavi, Babak Safavi, Amir Jalali, Ghazaleh Mohammadzadeh Shahriary, Javad Mohammadi-Asl, Javad Babaei   +5 more
doaj   +1 more source

Impact of CYP3A5 1* and 3* single nucleotide variants on tacrolimus pharmacokinetics and graft rejection risk in pediatric kidney transplant patients

Frontiers in Pharmacology
Tacrolimus, a calcineurin inhibitor, is widely used to prevent allograft rejection in kidney transplant recipients. Its metabolism is predominantly mediated by the cytochrome P450 3A5 (CYP3A5) enzyme, and single nucleotide variants (SNVs) within intron 3
Lesly Yanira Xajil-Ramos, Lesly Yanira Xajil-Ramos, Lesly Yanira Xajil-Ramos, Lesly Yanira Xajil-Ramos, Jesús Alonso Gándara-Mireles, Jesús Alonso Gándara-Mireles, Rodrigo José Vargas Rosales, Rodrigo José Vargas Rosales, Rodrigo José Vargas Rosales, Oscar Kevin Sánchez García, Andrea Mariela Ruano Toledo, Amy Kateleen Aldana de la Cruz, Ismael Lares-Asseff, Ismael Lares-Asseff, Leslie Patrón-Romero, Horacio Almanza-Reyes, Randall Lou-Meda   +16 more
doaj   +1 more source

Review: Ontogeny of oral drug absorption processes in children [PDF]

, 2012
A large proportion of prescribed drugs to children are administered orally. Age-related change in factors affecting oral absorption can have consequences for drug dosing. Areas covered: For each process affecting oral drug absorption, a systematic search
Huijsman, M.L. (Mark), Koning, B.A.E. (Barbara) de, Mooij, M.G. (Miriam), Wildt, S.N. (Saskia) de   +3 more
core   +4 more sources

CYP3A5 genotyping-guided dosing versus weight-based dosing in a multi-ethnic population of kidney transplant recipients

Proceedings of Singapore Healthcare
Introduction Tacrolimus is the cornerstone of immunosuppression after kidney transplantation (KTx) and is characterized by a narrow therapeutic index and large inter-individual variability.
Rou Wei Lim, Quan Yao Ho, Yan Ting Yeo, Ian Tatt Liew, Carolyn Shan-Yeu Tien, Sobhana Thangaraju, Puay Hoon Lee, Terence Kee   +7 more
doaj   +1 more source

Effects of CYP3A5 Polymorphisms on Efficacy and Safety of Tacrolimus Therapy in Patients with Idiopathic Membranous Nephropathy

Pharmacogenomics and Personalized Medicine, 2020
Chengning Zhang,1,* Suyan Duan,1,* Miao Guo,2 Yanggang Yuan,1 Zhimin Huang,1 Jingfeng Zhu,1 Bin Sun,1 Bo Zhang,1 Changying Xing1 1Departments of Nephrology; 2Department of Pharmacy, The First Affiliated Hospital of Nanjing Medical University, Nanjing ...
Zhang C, Duan S, Guo M, Yuan Y, Huang Z, Zhu J, Sun B, Zhang B, Xing C   +8 more
doaj  

CYP3A5 polymorphisms in renal transplant recipients: influence on tacrolimus treatment

Pharmacogenomics and Personalized Medicine, 2018
Lucy Chen,1 G V Ramesh Prasad2 1Kidney Transplant Program, St Michael’s Hospital, Toronto, ON, Canada; 2Division of Nephrology, St Michael’s Hospital, Toronto, ON, Canada Abstract: Tacrolimus is a commonly used immunosuppressant after ...
Chen L, Prasad GV
doaj  

CYP3A4 and CYP3A5 Genes in Cyclophosphamide-treated Chronic Lymphocytic Leukemia Patients: A Pharmacogenetics Study

Frontiers in Bioscience-Scholar
Background: Approximately 75% of drug metabolism in clinical settings is attributed to cytochrome P450 enzymes. This study aimed to assess the effects of the CYP3A4*1B and CYP3A5*3 genetic variations on the clinical results of ...
Heba M. Elmaraghy, Menna Al-Adl, Eman R. Saifeldein, Sahar M. Elashmony, Magdy M. Youssef, Afaf El-Said, Sherif Refaat, Abdallah E. Mohammed   +7 more
doaj   +1 more source

Metabolism of ticagrelor in patients with acute coronary syndromes. [PDF]

, 2018
© The Author(s) 2018Ticagrelor is a state-of-the-art antiplatelet agent used for the treatment of patients with acute coronary syndromes (ACS). Unlike remaining oral P2Y12 receptor inhibitors ticagrelor does not require metabolic activation to exert its ...
B Ibanez, C Varenhorst, D Alexopoulos, D Aradi, D Lindholm, D Zhou, EA Amsterdam, F Franchi, G Parodi, G Parodi, H Sillén, HS Smith, J Kubica, J Kubica, J Li, JH Cornel, JM Siller-Matula, K Butler, K Butler, K Thygesen, M Koziński, M Roffi, P Adamski, P Adamski, P Adamski, P Adamski, P Niezgoda, P Niezgoda, PG Steg, PG Steg, PT O’Gara, R Teng, R Teng, R Teng, R Teng, R Teng, R Teng, RA Lange, S Husted, S James, SE Husted, SS Brar   +41 more
core   +2 more sources

Individualization of Immunosuppressive Therapy after Solid Organ Transplantation [PDF]

, 2014
__Abstract__ When an individual’s kidneys fail, there are three treatment options: hemodialysis, peritoneal dialysis or kidney transplantation. A successful kidney transplantation results in the best patient survival and a better quality of life ...
Bouamar, R. (Rachida)
core   +1 more source

Genetic Causes of Clopidogrel Nonresponsiveness: Which Ones Really Count? [PDF]

, 2010
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/91111/1/phco.30.3.265 ...
Bates, Eric R., Dorsch, Michael P., Momary, Kathryn M.   +2 more
core   +1 more source