Results 101 to 110 of about 15,566 (231)

Irinotecan pathway genotype analysis to predict pharmacokinetics [PDF]

, 2003
PURPOSE: The purpose was to explore the relationships between irinotecan disposition and allelic variants of genes coding for adenosine triphosphate binding cassette transporters and enzymes of putative relevance for irinotecan ...
Baker, S.D. (Sharyn), Karlsson, M.O., Marsh, S. (Steven), Mathijssen, A.H.J. (Ron), McLeod, H.L. (Howard), Sparreboom, A. (Alex), Verweij, J. (Jaap), Xie, R. (Rujia)   +7 more
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CYP3A5 genetic polymorphism in HIV-patients [PDF]

, 2015
Poster presented at the From Basic Sciences to Clinical Research - First International Congress of CiiEM. Egas Moniz, Caparica, Portugal, 27-28 November 2015"A number of relevant polymorphisms are known for affecting the most common prescribed ARVs ...
Cruz, J. P., Fernandes, A., Martins, R., Morais, J. G., Ribeiro, A. C.   +4 more
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Lack of association between genetic variations in CYP3A5 and blood pressure or hypertension risk in the UK biobank

Frontiers in Genetics
IntroductionHypertension (HTN) is a leading risk factor for several cardiovascular diseases. While some previous studies reported that CYP3A5 variants were associated with decreased blood pressure and risk of HTN, others reported no associations ...
Pia Leibold, Christelle Lteif, Julio D. Duarte   +2 more
doaj   +1 more source

Genetic, ethnic, and gender differences in the pharmacokinetics of antiretroviral agents [PDF]

, 2018
Variable antiretroviral therapy (ART) drug response likely reflects the combined influence of environment, underlying disease, concurrent drugs, and genetics.
Csajka, Chantal, Rotger, Margalida, Telenti, Amalio   +2 more
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Impact of donor CYP3A5 genotype on pharmacokinetics of tacrolimus in South African paediatric liver transplant patients

South African Medical Journal
Background. In the paediatric liver transplant programme in Johannesburg, South Africa (SA), tacrolimus is the calcineurin inhibitor of choice, comprising an essential component of the immunosuppression regimen.
C Wheeler, C Masimirembwa, B Mthembu, J Botha, J Scholefield, J Fabian   +5 more
doaj   +1 more source

CYP3A-fenotype hos leddgiktpasienter i relasjon til inflammasjonsstatus og behandling med biologiske DMARDs [PDF]

, 2015
Bakgrunn: Enzymer tilhørende cytokrom P-450 3A (CYP3A)-subfamilien er de viktigste i metabolisme av legemidler. Systemisk inflammasjon er foreslått som en faktor til den store interindividuelle variabiliteten i CYP3A-fenotype, og 4β-hydroksykolesterol ...
Wollmann, Birgit Malene Tovik
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CYP3A5 promotes glioblastoma stemness and chemoresistance through fine-tuning NAD+/NADH ratio

Journal of Experimental & Clinical Cancer Research
Background Glioblastoma multiforme (GBM) exhibits a cellular hierarchy with a subpopulation of stem-like cells known as glioblastoma stem cells (GSCs) that drive tumor growth and contribute to treatment resistance.
Wentao Hu, Xiaoteng Cui, Hongyu Liu, Ze Li, Xu Chen, Qixue Wang, Guolu Zhang, Er Wen, Jinxin Lan, Junyi Chen, Jialin Liu, Chunsheng Kang, Ling Chen   +12 more
doaj   +1 more source

Functional polymorphisms in the CYP3A4, CYP3A5, and CYP21A2 genes in the risk for hypertension in pregnancy [PDF]

, 2010
An intronic single nucleotide polymorphism (SNP) in the CYP3A5 gene (CYP3A5*3; SNP rs776746) affects RNA splicing and enzymatic activity. The CYP3A5*3 frequency increased with distance from the equator and natural selection has been proposed to explain ...
Alonso, Belén, Corao, A.I. (Ana), Coto, Eliecer, Díaz, Marta, López, Carlos, Marín, Rafael, Ortega, Francisco, Ortiz, Alberto, Ruiz-Ortega, Marta, Tavira, Beatriz, Álvarez, Victoria   +10 more
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Drug–drug interaction between tacrolimus and caspofungin in Chinese kidney transplant patients with different genotypes

Therapeutic Advances in Drug Safety
Background: The effect of drug–drug interaction between tacrolimus and caspofungin on the pharmacokinetics of tacrolimus in different CYP3A5 genotypes has not been reported in previous studies.
Yundi Zhang, Bowen Shen, Yue Li, Huiying Zong, Xiaoming Zhang, Xiaohong Cao, Fengxi Liu, Yan Li   +7 more
doaj   +1 more source

Drug-drug interaction between diltiazem and tacrolimus in relation to CYP3A5 genotype status in Chinese pediatric patients with nephrotic range proteinuria: a retrospective study

Frontiers in Pharmacology
BackgroundTacrolimus is widely used to treat pediatric nephrotic range proteinuria (NRP). Diltiazem, a CYP3A4/5 inhibitor, is often administered with tacrolimus, affecting its pharmacokinetic profile. The impact of this combination on tacrolimus exposure,
Qiaoling Yang, Qiaoling Yang, Yan Wang, Yan Wang, Xuebin Wang, Ping Wang, Boyu Tan, Yijun Li, Huajun Sun, Wenyan Huang, Hongxia Liu   +10 more
doaj   +1 more source