Results 91 to 100 of about 821,395 (297)
Macrophages promote cyst growth in polycystic kidney disease.
Journal of the American Society of Nephrology, 2011 Polycystic kidney disease (PKD) exhibits an inflammatory component, but the contribution of inflammation to cyst progression is unknown. Macrophages promote the proliferation of tubular cells following ischemic injury, suggesting that they may have a ...
A. Karihaloo +7 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair +17 more
wiley +1 more source
Eukaryotic Cell, 2011 Type II Toxoplasma gondii KU80 knockouts (Δku80) deficient in nonhomologous end joining were developed to delete the dominant pathway mediating random integration of targeting episomes.
B. A. Fox +8 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.This article advocates integrating temporal dynamics into cancer research. Rather than relying on static snapshots, researchers should increasingly consider adopting dynamic methods—such as live imaging, temporal omics, and liquid biopsies—to track how tumors evolve over time.
Gautier Follain +3 more
wiley +1 more source
Aneurysmal bone cyst: a review of 150 patients.
Journal of Clinical Oncology, 2005 PURPOSE We have reviewed a series of 150 aneurysmal bone cysts treated over the last 20 years. PATIENTS AND METHODS The lesions were principally located in the tibia, femur, pelvis, humerus, and spine and, in most cases, presented the imaging ...
H. Mankin +4 more
semanticscholar +1 more source
Evaluation of synaptotagmin‐1 action models by all‐atom molecular dynamics simulations
FEBS Open Bio, EarlyView.We used molecular dynamics simulations to test models proposing that synaptotagmin‐1 facilitates membrane fusion by perturbing lipid bilayers, inducing membrane curvature and/or bridging membranes. The simulations show that synaptotagmin‐1 C2‐domains placed near the site of fusion hinder the ability of SNARE complexes to bring the membranes together ...
Josep Rizo +2 more
wiley +1 more source
Journal of Experimental Botany, 2008 Cyst nematodes are highly evolved sedentary plant endoparasites that use parasitism proteins injected through the stylet into host tissues to successfully parasitize plants.
Anoop S. Sindhu +5 more
semanticscholar +1 more source
Red blood cells could protect miRNAs from degradation or loss thanks to Argonaute 2 binding
FEBS Open Bio, EarlyView.The present work investigates the presence and the stability of miRNAs into RBCs, both native and engineered. The observed stability is due to the Ago2 bound resulting in minimal RISC. Indeed, if the miRNA‐Ago2 complex is present, miRNAs are protected from release or degradation and they are biologically active. Thus, RBCs can act as miRNA carriers for
Elena Perla +4 more
wiley +1 more source
Assessment of glucose levels in cyst fluid aspirates to evaluate cellular metabolism
SRM Journal of Research in Dental Sciences, 2017 Aim and Objectives: The aim of the study was to analyze glucose content of cyst fluid to assess the cellular metabolism. Objectives were to analyze glucose level in cyst aspirates of dentigerous, odontogenic keratocysts, radicular, and residual cysts to ...
Shailja Chatterjee, Asha Karadwal
doaj +1 more source
Human Molecular Genetics, 2008 Polycystic kidney disease (PKD) is an inherited disorder that is characterized by the accumulation of cysts in the renal parenchyma and progressive decline in renal function. Recent studies suggest that PKD arises from abnormalities of the primary cilium.
V. Patel +6 more
semanticscholar +1 more source