Exosome Proteomics of SOD1D90A Mutation Suggest Early Disease Mechanisms, and FN1 as a Biomarker
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Amyotrophic lateral sclerosis (ALS) is a neuromuscular disease. Super oxide dismutase 1 (SOD1) gene mutations cause ALS, and the D90A mutation is associated with primarily upper motor neuron (UMN) loss. Objective Our goal is to reveal the early cellular events in ALS pathology and identify potential pharmacokinetic biomarkers, using well ...
Mukesh Gautam +6 more
wiley +1 more source
Innovative Strategy toward Mutant CFTR Rescue in Cystic Fibrosis: Design and Synthesis of Thiadiazole Inhibitors of the E3 Ligase RNF5 [PDF]
, 2023 Irene Brusa +15 more
openalex +1 more source
Eukaryotic Cell, 2011 Type II Toxoplasma gondii KU80 knockouts (Δku80) deficient in nonhomologous end joining were developed to delete the dominant pathway mediating random integration of targeting episomes.
B. A. Fox +8 more
semanticscholar +1 more source
The Multigeneic _Rhg1_ Locus: A Model For The Effects on Root Development, Nematode Resistance and Recombination Suppression. [PDF]
, 2008 Soybean (Glycine max L. Merr.) resistance to populations (HgType) of _Heterodera glycines I._, the soybean cyst nematode (SCN), requires a functional allele at rhg1. An apoptosis-like response in the giant cells formed around the nematode results 24-48 h
Ali Srour +3 more
core +2 more sources
Pathology associated with larval Eustrongylides sp. (Nematoda: Dioctophymatoidea) infection in Galaxias maculatus (Actinopterygii: Galaxiidae) from Patagonia, Argentina [PDF]
, 2019 Helminth infections within tissues tend to be subjected to a host response that can include encapsulation and melanization to isolate the parasite. The effectiveness of this response depends on the host species. During a survey of parasites of the native
Brugni, Norma Leonor +2 more
core +1 more source
SNUPN‐Related Muscular Dystrophy: Novel Phenotypic, Pathological and Functional Protein Insights
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective SNUPN‐related muscular dystrophy or LGMDR29 is a new entity that covers from a congenital or childhood onset pure muscular dystrophy to more complex phenotypes combining neurodevelopmental features, cataracts, or spinocerebellar ataxia. So far, 12 different variants have been described.
Nuria Muelas +18 more
wiley +1 more source
t‐SNAREs bind the Rhg1 α‐SNAP and mediate soybean cyst nematode resistance [PDF]
, 2020 Dong Jia +2 more
openalex +1 more source
Thyroglossal Duct Cyst Carcinoma: A Surgical Enigma [PDF]
Journal of Clinical and Diagnostic ResearchDear Editor, A 62-year-old woman, with no medical co-morbidities, presented with a midline neck swelling that had evolved over eight years. She denied neck irradiation in childhood and had neither associated hypo- nor hyperthyroidism nor any pressure ...
Priyadarshan Anand Jategaonkar
doaj +1 more source
New organic-walled dinoflagellate cysts from recent sediments of central Asian seas [PDF]
, 2004 Recent to sub-recent sediments from the Caspian Sea, the Kara-Bogaz-Gol Bay, the Enseli lake and the Aral Sea contain the new organic-walled dinoflagellate cysts Caspidinium, Caspidinium rugosum and Impagidinium caspienense.
Chalié, F +3 more
core +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Introduction Neuronal pentraxin 2 (NPTX2) is a synaptic protein involved in synaptic plasticity and regulation of neuronal excitability. Lower baseline cerebrospinal fluid (CSF) NPTX2 levels have been shown to be associated with an earlier onset of mild cognitive impairment (MCI), a pre‐dementia syndrome, even after CSF Alzheimer's Disease (AD)
Juan P. Vazquez +12 more
wiley +1 more source