Results 101 to 110 of about 1,311,005 (280)

Restores Aβ Clearance by Overcoming PCSK9–LRP1 Dysregulation and TRIB3‐Mediated Autophagy Blockade in Alzheimer's Disease

Advanced Science, EarlyView.
PCSK9 upregulation in cerebrovascular endothelial cells and microglia destabilizes the Aβ transporter LRP1, while TRIB3‐associated autophagy blockade further limits intracellular Aβ degradation. A RAP‐modified tea‐polyphenol nanoparticle co‐delivers siPCSK9 and siTRIB3 to restore LRP1‐mediated Aβ efflux and autophagy‐dependent degradation, reducing Aβ ...
Jie Miao, Jing Wang, Yankun Li, Haipei Zhang, Yanli Zhang, Qingnian Li, Bo Xiao, Wenhu Zhou, Junhong Guo   +8 more
wiley   +1 more source

Remote Ischemic Post‐Conditioning Preserves the Neurovascular Unit by Brain‐Derived Gas6 That Drives Monocyte‐Derived Macrophage Reprogramming via Axl and Vimentin after SAH

Advanced Science, EarlyView.
Subarachnoid hemorrhage (SAH) triggers monocyte‐derived macrophage (MDM) infiltration and M1‐like polarization via Vimentin upregulation, leading to neurovascular unit disruption and cognitive dysfunction. Remote ischemic postconditioning (RIPostC) upregulates neuronal Gas6, which activates Axl on MDMs to downregulate Vimentin and drive reparative M2 ...
Yajun Zhu, Zichao Huang, Xi Rong, Xingwei Lei, Fuming Liang, Xiaoguo Li, Jiru Zhou, Yu Wang, Yifan Huang, Shuang Tang, Jianjun Zhong, Jin Yan, Hongji Deng, Chun Zeng, Zongduo Guo   +14 more
wiley   +1 more source

Giant Primary Conjunctival Inclusion Cyst: A Case Report and Brief Literature Review

TNOA Journal of Ophthalmic Science and Research
A conjunctival cyst is a slow-growing benign lesion that forms beneath or on the conjunctiva. Inclusion cysts contribute to most cases, more commonly secondary than primary.
Shilpa S. Reddy, Jasmita Satapathy, Sucharita Das, Pranita Mohanty, Ajay D. Syal   +4 more
doaj   +1 more source

Ultrastructural studies of sarcocystis cruzi (Hasselmann,1926) Wenyon, 1926 infection in cattle (Bos Taurus): Philippine cases

Parasite, 2001
This paper documents the first report of Sarcocysli s cruzi infection in domesticated cattle (Bos taurus) in the Philippines. Fusiformshaped microscopic sarcocysts (183-578 μm long and 20-98 μm wide) with distinct septae were found in the skeletal ...
Claveria F.G, San-Pedro Lim.R, Cruz-Flores M.J, Nagasawa H., Suzuki N., De la Peña C.   +5 more
doaj   +1 more source

Galactokinase 1 Positively Regulates Mitochondrial Respiration by Phosphorylating TIMM13 as a Protein Kinase

Advanced Science, EarlyView.
GALK1 acts as a protein kinase beyond the phosphorylation of galactose. GALK1 phosphorylates TIMM13 at Y73 in the cytoplasm. This phosphorylation prevents premature oxidative folding of TIMM13 and ensures its entrance into the intermembrane space of mitochondrion, positively regulating mitochondrial respiration.
Chang Woo Ko, Dongyoon Shin, Junho Park, June Huh, Youngsoo Kim, Jong‐Wan Park   +5 more
wiley   +1 more source

Anionic sites on Toxoplasma gondii tissue cyst wall: Expression, uptake and characterization

, 2007
Toxoplasmosis, caused by Toxoplasma gondii, is an important parasitic disease worldwide, which causes widespread human and animal diseases. The need for new therapeutic agents along with the biology of these parasites has fueled a keen interest in the ...
Guimarães, Erick Vaz, Helene Santos Barbosa, Acquarone, Mariana, Carvalho, Laís de, Erick Vaz Guimarães, Mariana Acquarone, Laís de Carvalho, Barbosa, Helene Santos   +7 more
core   +1 more source

Neonatal Sevoflurane Exposure Induces Long‐Term Cognitive Impairment via Epigenetically Mediated MMP9 Activation and Perineuronal Net Disruption in the Hippocampal CA2

Advanced Science, EarlyView.
Hippocampal CA2 perineuronal nets ensheathing excitatory pyramidal neurons are selectively vulnerable to repeated neonatal sevoflurane exposure. Epigenetic upregulation of MMP9 via reduced H3K27me3 disrupts PNN integrity, impairs BDNF–TrkB signaling, and causes synaptic protein loss and dendritic spine deficits, leading to persistent social and spatial
Lirong Liang, Jiachen Wang, Taozhi Wang, Yanling Li, Youyi Zhao, Guanghui Hao, Peiqin Gong, Ruling Chen, Yilin Fang, Shengxi Wu, Haopeng Zhang, Hui Zhang   +11 more
wiley   +1 more source

Monoclonal antibody SalmonE binds to the cyst wall of cysts isolated in vitro and in vivo.

, 2013
(A) Human foreskin fibroblasts (HFF) were infected with ME49 strain of T. gondii under alkaline conditions (pH 8.1) for 3 days. Anti-BAG1 antibody (red) staining demonstrates that the smaller parasitophorous vacuole on the right is an in vitro cyst; mAb ...
Louis M. Weiss (82467), Yan Fen Ma (501932), David J. Bzik (206407), Tadakimi Tomita (501931), Barbara A. Fox (206394), Ronald C. Taylor (93848), Lye Meng Markillie (423748), Kami Kim (207464)   +7 more
core   +1 more source

Huntingtin Aggregate‐Responsive Autophagy Gene Circuit Mitigates Disease Pathology in R6/2 Mice

Advanced Science, EarlyView.
CD98‐mediated receptor‐mediated transcytosis enables LIP‐CD98 nanocarriers to cross the blood–brain barrier and deliver ARAA to neurons. mHTT aggregates activate the 11G–NarX sensor, initiating Auto‐P and Trans‐P signaling through the VP48–NarL relay.
Jie Zhu, Xi‐xiu Xie, Lei Li, Chen Tian, Hao‐tian Wang, Xiao‐jie Wang, Xiao‐lin Yu, Gui‐feng Zhang, Rui‐tian Liu   +8 more
wiley   +1 more source

Arthroscopic internal drainage of popliteal cysts with cyst wall resection in pediatric patients. [PDF]

Pak J Med Sci, 2022
Zhu J, Xiang D, Yang S, Xiang L, Liu X.
europepmc   +1 more source