Results 191 to 200 of about 1,311,005 (280)

The β integrin modulates serotonin sensitivity via NPxY motifs to regulate egg laying and mechanosensation behaviors in Caenorhabditis elegans

Developmental Dynamics, EarlyView.
Abstract Background Integrin is an αβ heterodimeric receptor to the extracellular matrix; its binding to the matrix recruits focal adhesions to two NPxY motifs, the tyrosine phosphorylation sites in the cytoplasmic domain. Studies found that replacing tyrosines (Y) with phenylalanines (F) in the motif of β1 integrin displayed little developmental or ...
Josh Haram Bumm, Daniel Dogeon Lee, Zhongqiang Qiu, Angela Haeun Choi, Meghana Kolluri, Michael J. Olsen, Lianzijun Wang, Myeongwoo Lee   +7 more
wiley   +1 more source

Commonalities of platelet dysfunction in heart failure with preserved ejection fraction and underlying comorbidities

ESC Heart Failure, Volume 12, Issue 2, Page 1013-1028, April 2025.
Abstract Heart failure with preserved ejection fraction (HFpEF) is characterized by a lack of a specific targeted treatment and a complex, partially unexplored pathophysiology. Common comorbidities associated with HFpEF are hypertension, atrial fibrillation, obesity and diabetes.
Giorgia D'Italia, Blanche Schroen, Judith M.E.M. Cosemans   +2 more
wiley   +1 more source

Localizing value of ecstatic phenomenon in epilepsy surgery: A systematic review

Epileptic Disorders, EarlyView.
Abstract Objective A systematic review was conducted to synthesize current anatomo‐clinical correlations of ecstatic symptoms in focal epilepsy, aiming to provide evidence‐based guidance for interpreting this ictal semiology during presurgical evaluation.
Mihai Dragos Maliia, Fabrice Bartolomei, Fabienne Picard   +2 more
wiley   +1 more source

Metabolic Nanomedicine Reprograms Mesenchymal Stem Cells for Durable Exosome‐Mediated Immunomodulation

Exploration, EarlyView.
Prolonged inflammatory stress depletes NAD+ in mesenchymal stem cells, driving functional exhaustion and weakening their survival and immune‐regulating activity. We developed an NAD+‐delivering nanomedicine that restores cellular metabolism and improves therapeutic efficacy in colitis.
Jinfeng Chen, Kanghua Zeng, Jinhong Chao, Xiangna Zhang, Zheng Zhou, Xiang Li, Wancheng Liu, Xiahong Xie, Luyao Wang, Mingzhou Ye   +9 more
wiley   +1 more source

Cellulose fibrils formation and organisation of cytoskeleton during encystment are essential for Acanthamoeba cyst wall architecture. [PDF]

Sci Rep, 2019
Garajová M, Mrva M, Vaškovicová N, Martinka M, Melicherová J, Valigurová A.   +5 more
europepmc   +1 more source

Embodied attachments: IVF, the maternal body, and the making of embryo kinship

Feminist Anthropology, EarlyView.
Abstract Within the sphere of IVF (in vitro fertilization), there is increasing concern about the stockpiles of frozen embryos held in clinics across the country. This normative discourse tends to take the patient‐embryo relationship for granted, with salient political consequences for current embryo ‘personhood’ debates.
Manon Lefevre
wiley   +1 more source

Evaluation of the Toxicity, Morphological and Behavioural Effects of Pelargonium graveolens Essential Oil in Artemia franciscana, Along With Its Antimicrobial Activity

Flavour and Fragrance Journal, EarlyView.
Essential oil of Pelargonium graveolens exhibited potent antimicrobial activity against bacterial and fungal pathogens, while higher concentrations induced mortality and altered swimming behaviour in Artemia franciscana. These findings highlight its therapeutic potential and underscore the importance of defining safe concentration ranges to support ...
Silvana de Oliveira, Caio Alexandre de Freitas Schatzer, Tiago Schena, Fernanda Dias da Silva, Elizabeth Teodorov   +4 more
wiley   +1 more source

Illuminating point‐of‐care diagnostics with aggregation‐induced emission biosensors

FlexMat, EarlyView.
This review highlights the application of aggregation‐induced emission luminogens (AIEgens) in point‐of‐care (POC) diagnostics for disease biomarker detection. It systematically examines a range of biosensing platforms, including lateral flow immunoassays, microfluidic chips, and electrochemiluminescence sensors, alongside their utility in detecting ...
Danni Hu, Yubing Hu, Dong Wang, Ben Zhong Tang   +3 more
wiley   +1 more source

A Giant Proliferating Trichilemmal Tumor of the Perineum with Pelvic Extension: Transperineal Resection Facilitated by Cyst Fluid Redistribution and Enhanced Perineal Expansion. [PDF]

Surg Case Rep
Kojima M, Miyake T, Tani S, Muramoto K, Sonoda T, Isogawa K, Kaida S, Takebayashi K, Maehira H, Mori H, Otake R, Nitta N, Shimizu T.   +12 more
europepmc   +1 more source

Extracellular vesicles derived from edible plants and edible fungi: Compositional characteristics, engineering strategies and biofunctions

Food Biomacromolecules, EarlyView.
Non‐animal extracellular vesicles as bioactive‐compound carriers: compositional characteristics, engineering strategies, and biofunctions. Abstract Animal‐derived extracellular vesicles (EVs) were widely used for bioactive compound delivery but constrained by complex origins, potential immunogenicity, and pathogen contamination.
Jiahao Yu, Rongheng Chen, Yuxuan Liu, Yizhen Xie, Fangyu Fan, Simin Feng, Ping Shao   +6 more
wiley   +1 more source